Pharmacology of adenosine receptors: the state of the art
Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …
Immunity, inflammation and cancer: a leading role for adenosine
Cancer is a complex disease that is dictated by both cancer cell-intrinsic and cell-extrinsic
processes. Adenosine is an ancient extracellular signalling molecule that can regulate …
processes. Adenosine is an ancient extracellular signalling molecule that can regulate …
Extracellular purines, purinergic receptors and tumor growth
F Di Virgilio, E Adinolfi - Oncogene, 2017 - nature.com
Virtually, all tumor cells as well as all immune cells express plasma membrane receptors for
extracellular nucleosides (adenosine) and nucleotides (ATP, ADP, UTP, UDP and sugar …
extracellular nucleosides (adenosine) and nucleotides (ATP, ADP, UTP, UDP and sugar …
Immunological landscape and immunotherapy of hepatocellular carcinoma
J Prieto, I Melero, B Sangro - Nature reviews Gastroenterology & …, 2015 - nature.com
Advanced hepatocellular carcinoma (HCC) is a serious therapeutic challenge and targeted
therapies only provide a modest benefit in terms of overall survival. Novel approaches are …
therapies only provide a modest benefit in terms of overall survival. Novel approaches are …
Targets of immune escape mechanisms in cancer: basis for development and evolution of cancer immune checkpoint inhibitors
Simple Summary The tumor immune escape mechanisms are key factors in cancer
progression and metastasis. They are an undeniable hurdle for successful cancer treatment …
progression and metastasis. They are an undeniable hurdle for successful cancer treatment …
Machine and deep learning approaches for cancer drug repurposing
Abstract Knowledge of the underpinnings of cancer initiation, progression and metastasis
has increased exponentially in recent years. Advanced “omics” coupled with machine …
has increased exponentially in recent years. Advanced “omics” coupled with machine …
Adenosine as a multi-signalling guardian angel in human diseases: when, where and how does it exert its protective effects?
The importance of adenosine for human health cannot be overstated. Indeed, this ubiquitous
nucleoside is an integral component of ATP, and regulates the function of every tissue and …
nucleoside is an integral component of ATP, and regulates the function of every tissue and …
Focusing on adenosine receptors as a potential targeted therapy in human diseases
Adenosine is involved in a range of physiological and pathological effects through
membrane-bound receptors linked to G proteins. There are four subtypes of adenosine …
membrane-bound receptors linked to G proteins. There are four subtypes of adenosine …
Immune response dysfunction in chronic lymphocytic leukemia: dissecting molecular mechanisms and microenvironmental conditions
F Arruga, BB Gyau, A Iannello, N Vitale… - International journal of …, 2020 - mdpi.com
Representing the major cause of morbidity and mortality for chronic lymphocytic leukemia
(CLL) patients, immunosuppression is a common feature of the disease. Effectors of the …
(CLL) patients, immunosuppression is a common feature of the disease. Effectors of the …
Cancer biology and molecular genetics of A3 adenosine receptor
Abstract A3 adenosine receptor (A3AR) is a cell membrane protein, which has been found to
be overexpressed in a large number of cancer types. This receptor plays an important role in …
be overexpressed in a large number of cancer types. This receptor plays an important role in …