Background Pyroptosis mediated by NLRP3 inflammasome plays a critical role in the
pathogenesis of cerebral ischemia-reperfusion (I/R) injury. Mounting evidences have …

Designing translational antioxidative agents that could scavenge free radicals produced
during reperfusion in brain ischemia stroke and alleviate neurologic damage is the main …

Purpose Cerebral ischemia induces a profound neuro-inflammatory response, but the
underlying molecular mechanisms are poorly understood. Inflammasomes (NLRP1, NLRP3 …

Background Blood–brain barrier (BBB) disruption is a major adverse event after ischemic
stroke (IS). Caveolin-1 (Cav-1), a scaffolding protein, played multiple roles in BBB …

Central nervous system (CNS) function recovery following stroke remains a major challenge
because neural regeneration is difficult to achieve. In this study, rigid-flexible composite …

Blood–brain barrier (BBB) dysfunction, characterized by degradation of BBB junctional
proteins and increased permeability, is a crucial pathophysiological feature of acute …

Aims To explore the therapeutic effect and possible mechanism of exosomes from MSCs
overexpressing miR-223 on cerebral ischemia and microglia polarization mediated …

Edaravone dexborneol (EDB) is a traditional prescription that consists of two components,
edaravone and (+)-borneol, which have synergistic antioxidant and anti-inflammatory …

Stroke remains one of the most important causes of death and disability. Preclinical research
is a powerful tool for understanding the molecular and cellular response to stroke. However …

The protective effects of remote ischemic conditioning (RIC) on acute ischemic stroke have
been reported. However, the protective mechanisms of RIC have not been fully elucidated …