In recent years, a variety of receptor-targeted fluorescent probes have been developed and
widely used to realize the visualization of certain receptors, which facilitates the early …

In recent years, several novel aspects of GPCR pharmacology have been described, which
are thought to play a role in determining the in vivo efficacy of a compound. Fluorescent …

Identifying neurons that have functional opioid receptors is fundamental for the
understanding of the cellular, synaptic and systems actions of opioids. Current techniques …

Introduction: G-protein-coupled receptors (GPCRs) mediate the effects of approximately
33% of all marketed drugs. The development of tools to study GPCR pharmacology is …

Abstract Scientists Robert J. Lefkowitz and Brian K. Kobilka won the Nobel Prize in 2012 for
reporting a groundbreaking discovery that revealed a crucial member of the receptor family …

Cannabinoid type 2 receptor (CB2R) is an attractive target for the treatment of pain and
inflammatory disorders. Availability of a selective CB2R fluorescent ligand to study CB2R …

The opioids are powerful analgesics yet possess contingencies that can lead to opioid‐use
disorder. Chemical probes derived from the opioid alkaloids can provide deeper insight into …

Opioid receptors (ORs) are among the best-studied G protein-coupled receptors due to their
involvement in neurological disorders and important role in pain treatment. Contrary to the …

The delta opioid receptor (δOR or DOR) is a G protein-coupled receptor (GPCR) showing a
promising profile as a drug target for nociception and analgesia. Herein, we design and …

An unprecedented sequential [3+ 3]/[3+ 3] annulation of allenoates and dienes catalyzed by
phosphine has been developed, which provides novel and facile access to highly …