DNA damage kinase signaling: checkpoint and repair at 30 years
From bacteria to mammalian cells, damaged DNA is sensed and targeted by DNA repair
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …
Histone phosphorylation: a chromatin modification involved in diverse nuclear events
D Rossetto, N Avvakumov, J Côté - Epigenetics, 2012 - Taylor & Francis
Histone posttranslational modifications are key components of diverse processes that
modulate chromatin structure. These marks function as signals during various chromatin …
modulate chromatin structure. These marks function as signals during various chromatin …
Comprehensive map** of histone modifications at DNA double-strand breaks deciphers repair pathway chromatin signatures
Double-strand breaks (DSBs) are extremely detrimental DNA lesions that can lead to cancer-
driving mutations and translocations. Non-homologous end joining (NHEJ) and homologous …
driving mutations and translocations. Non-homologous end joining (NHEJ) and homologous …
γH2AX: a sensitive molecular marker of DNA damage and repair
LJ Mah, A El-Osta, TC Karagiannis - Leukemia, 2010 - nature.com
Phosphorylation of the Ser-139 residue of the histone variant H2AX, forming γH2AX, is an
early cellular response to the induction of DNA double-strand breaks. Detection of this …
early cellular response to the induction of DNA double-strand breaks. Detection of this …
ATP-dependent chromatin remodeling: genetics, genomics and mechanisms
DC Hargreaves, GR Crabtree - Cell research, 2011 - nature.com
Macromolecular assemblies that regulate chromatin structure using the energy of ATP
hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of …
hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of …
Chromatin context-dependent regulation and epigenetic manipulation of prime editing
We set out to exhaustively characterize the impact of the cis-chromatin environment on
prime editing, a precise genome engineering tool. Using a highly sensitive method for …
prime editing, a precise genome engineering tool. Using a highly sensitive method for …
The biology of chromatin remodeling complexes
CR Clapier, BR Cairns - Annual review of biochemistry, 2009 - annualreviews.org
The packaging of chromosomal DNA by nucleosomes condenses and organizes the
genome, but occludes many regulatory DNA elements. However, this constraint also allows …
genome, but occludes many regulatory DNA elements. However, this constraint also allows …
Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae
LS Symington, R Rothstein, M Lisby - Genetics, 2014 - academic.oup.com
Homology-dependent exchange of genetic information between DNA molecules has a
profound impact on the maintenance of genome integrity by facilitating error-free DNA …
profound impact on the maintenance of genome integrity by facilitating error-free DNA …
γH2AX and cancer
WM Bonner, CE Redon, JS Dickey… - Nature Reviews …, 2008 - nature.com
Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …
γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
A Kinner, W Wu, C Staudt, G Iliakis - Nucleic acids research, 2008 - academic.oup.com
DNA double-strand breaks (DSBs) are extremely dangerous lesions with severe
consequences for cell survival and the maintenance of genomic stability. In higher …
consequences for cell survival and the maintenance of genomic stability. In higher …