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Spinal cord injury: molecular mechanisms and therapeutic interventions
X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …
The challenges of SCI repair include its complex pathological mechanisms and the …
The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities
X He, Y Li, B Deng, A Lin, G Zhang, M Ma… - Cell …, 2022 - Wiley Online Library
Abstract Objects Traumatic spinal cord injury (TSCI) causes neurological dysfunction below
the injured segment of the spinal cord, which significantly impacts the quality of life in …
the injured segment of the spinal cord, which significantly impacts the quality of life in …
[HTML][HTML] Inflammation: a target for treatment in spinal cord injury
X Freyermuth-Trujillo, JJ Segura-Uribe… - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …
Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …
socioeconomic implications for patients and their care-givers. Recent advances in medical …
Intranasal delivery of mesenchymal stem cell derived exosomes loaded with phosphatase and tensin homolog siRNA repairs complete spinal cord injury
Individuals with spinal cord injury (SCI) usually suffer from permanent neurological deficits,
while spontaneous recovery and therapeutic efficacy are limited. Here, we demonstrate that …
while spontaneous recovery and therapeutic efficacy are limited. Here, we demonstrate that …
Microenvironment imbalance of spinal cord injury
B Fan, Z Wei, X Yao, G Shi, X Cheng… - Cell …, 2018 - journals.sagepub.com
Spinal cord injury (SCI), for which there currently is no cure, is a heavy burden on patient
physiology and psychology. The microenvironment of the injured spinal cord is complicated …
physiology and psychology. The microenvironment of the injured spinal cord is complicated …
Review of advances in electrospinning-based strategies for spinal cord regeneration
Spinal cord injury (SCI) is a devastating neurological condition, commonly leading to
physical and mental deficiencies, pain, other complications, and even death. Most recently …
physical and mental deficiencies, pain, other complications, and even death. Most recently …
A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury
Spinal cord injury (SCI) creates an inflammatory microenvironment characterized by
damage-associated molecular patterns (DAMPs) and immune cell activation that exacerbate …
damage-associated molecular patterns (DAMPs) and immune cell activation that exacerbate …
Pretreatment with kaempferol attenuates microglia-mediate neuroinflammation by inhibiting MAPKs–NF–κB signaling pathway and pyroptosis after secondary spinal …
Z Liu, X Yao, B Sun, W Jiang, C Liao, X Dai… - Free Radical Biology …, 2021 - Elsevier
Spinal cord injury (SCI) is a devastating injury that characterized by oxidative stress and
inflammatory response. Kaempferol is reported to be an anti-neuroinflammation in …
inflammatory response. Kaempferol is reported to be an anti-neuroinflammation in …
Porous microneedle patch with sustained delivery of extracellular vesicles mitigates severe spinal cord injury
The transplantation of mesenchymal stem cells-derived secretome, particularly extracellular
vesicles is a promising therapy to suppress spinal cord injury-triggered neuroinflammation …
vesicles is a promising therapy to suppress spinal cord injury-triggered neuroinflammation …