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Choose your own adventure: A comprehensive database of reactions catalyzed by cytochrome P450 BM3 variants
DJ Fansher, JN Besna, A Fendri, JN Pelletier - ACS catalysis, 2024 - ACS Publications
Cytochrome P450 BM3 monooxygenase is the topic of extensive research as many
researchers have evolved this enzyme to generate a variety of products. However, the …
researchers have evolved this enzyme to generate a variety of products. However, the …
Engineered microbes as effective tools for the remediation of polyaromatic aromatic hydrocarbons and heavy metals
Heavy metals (HMs) and polycyclic aromatic hydrocarbons (PAHs) have become a major
concern to human health and the environment due to rapid industrialization and …
concern to human health and the environment due to rapid industrialization and …
Constructing Protein-Scaffolded Multienzyme Assembly Enhances the Coupling Efficiency of the P450 System for Efficient Daidzein Biosynthesis from (2S) …
Z Wang, Y Dai, F Azi, Z Wang, W Xu… - Journal of agricultural …, 2024 - ACS Publications
Daidzein is a major isoflavone compound with an immense pharmaceutical value. This
study applied a novel P450 CYP82D26 which can biosynthesize daidzein from (2 S) …
study applied a novel P450 CYP82D26 which can biosynthesize daidzein from (2 S) …
Synthetically engineered microbial scavengers for enhanced bioremediation
Microbial bioremediation has gained attention as a cheap, efficient, and sustainable
technology to manage the increasing environmental pollution. Since microorganisms in …
technology to manage the increasing environmental pollution. Since microorganisms in …
[HTML][HTML] Growth-coupled enzyme engineering through manipulation of redox cofactor regeneration
Enzymes need to be efficient, robust, and highly specific for their effective use in commercial
bioproduction. These properties can be introduced using various enzyme engineering …
bioproduction. These properties can be introduced using various enzyme engineering …
Current trend of polycyclic aromatic hydrocarbon bioremediation: Mechanism, artificial mixed microbial strategy, machine learning, ground application, cost and policy …
D Baskaran, HS Byun - Chemical Engineering Journal, 2024 - Elsevier
Global market growth has increased demand for non-renewable fossil fuels, posing a threat
to the environment and human health. Environmentalists seek eco-friendly ways to treat …
to the environment and human health. Environmentalists seek eco-friendly ways to treat …
Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform
Noncanonical redox cofactors are attractive low-cost alternatives to nicotinamide adenine
dinucleotide (phosphate)(NAD (P)+) in biotransformation. However, engineering enzymes to …
dinucleotide (phosphate)(NAD (P)+) in biotransformation. However, engineering enzymes to …
The molecular basis and enzyme engineering strategies for improvement of coupling efficiency in cytochrome P450s
Cytochrome P450s are heme-thiolate enzymes that have been broadly applied in
pharmaceutical and biosynthesis because of their efficient oxidation at inert carbons …
pharmaceutical and biosynthesis because of their efficient oxidation at inert carbons …
Growth‐Coupled Evolutionary Pressure Improving Epimerases for D‐Allulose Biosynthesis Using a Biosensor‐Assisted In Vivo Selection Platform
C Li, X Gao, H Li, T Wang, F Lu, HM Qin - Advanced Science, 2024 - Wiley Online Library
Fast screening strategies that enable high‐throughput evaluation and identification of
desired variants from diversified enzyme libraries are crucial to tailoring biocatalysts for the …
desired variants from diversified enzyme libraries are crucial to tailoring biocatalysts for the …
Orthogonal glycolytic pathway enables directed evolution of noncanonical cofactor oxidase
Noncanonical cofactor biomimetics (NCBs) such as nicotinamide mononucleotide (NMN+)
provide enhanced scalability for biomanufacturing. However, engineering enzymes to …
provide enhanced scalability for biomanufacturing. However, engineering enzymes to …