Risk factors for progression of age‐related macular degeneration

TJ Heesterbeek, L Lorés‐Motta… - Ophthalmic and …, 2020 - Wiley Online Library
Purpose Age‐related macular degeneration (AMD) is a degenerative disease of the macula,
often leading to progressive vision loss. The rate of disease progression can vary among …

[HTML][HTML] Artificial intelligence in retina

U Schmidt-Erfurth, A Sadeghipour, BS Gerendas… - Progress in retinal and …, 2018 - Elsevier
Major advances in diagnostic technologies are offering unprecedented insight into the
condition of the retina and beyond ocular disease. Digital images providing millions of …

[HTML][HTML] Integration of eQTL and a single-cell atlas in the human eye identifies causal genes for age-related macular degeneration

LD Orozco, HH Chen, C Cox, KJ Katschke, R Arceo… - Cell reports, 2020 - cell.com
Age-related macular degeneration (AMD) is a leading cause of vision loss. To better
understand disease pathogenesis and identify causal genes in GWAS loci for AMD risk, we …

The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD

S Ghosh, R Sharma, S Bammidi, V Koontz… - Nature …, 2024 - nature.com
Non-neovascular or dry age-related macular degeneration (AMD) is a multi-factorial disease
with degeneration of the aging retinal-pigmented epithelium (RPE). Lysosomes play a …

Deep-learning-based prediction of late age-related macular degeneration progression

Q Yan, DE Weeks, H **n, A Swaroop… - Nature machine …, 2020 - nature.com
Both genetic and environmental factors influence the etiology of age-related macular
degeneration (AMD), a leading cause of blindness. AMD severity is primarily measured by …

Sigma-2 receptors—from basic biology to therapeutic target: a focus on age-related degenerative diseases

BN Lizama, J Kahle, SM Catalano… - International journal of …, 2023 - mdpi.com
There is a large unmet medical need to develop disease-modifying treatment options for
individuals with age-related degenerative diseases of the central nervous system. The …

A systems biology approach uncovers novel disease mechanisms in age-related macular degeneration

LD Orozco, LA Owen, J Hofmann, AD Stockwell, J Tao… - Cell genomics, 2023 - cell.com
Age-related macular degeneration (AMD) is a leading cause of blindness, affecting 200
million people worldwide. To identify genes that could be targeted for treatment, we created …

Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model

R Sharma, A George, M Nimmagadda… - Nature …, 2021 - nature.com
Abstract Age-related Macular Degeneration (AMD), a blinding eye disease, is characterized
by pathological protein-and lipid-rich drusen deposits underneath the retinal pigment …

Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration

A Senabouth, M Daniszewski, GE Lidgerwood… - Nature …, 2022 - nature.com
There are currently no treatments for geographic atrophy, the advanced form of age-related
macular degeneration. Hence, innovative studies are needed to model this condition and …

Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock

S Ahadi, KA Wilson, B Babenko, CY McLean, D Bryant… - Elife, 2023 - elifesciences.org
Biological age, distinct from an individual's chronological age, has been studied extensively
through predictive aging clocks. However, these clocks have limited accuracy in short time …