Gene drives gaining speed
E Bier - Nature Reviews Genetics, 2022 - nature.com
Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …
Is it time for synthetic biodiversity conservation?
Evidence indicates that, despite some critical successes, current conservation approaches
are not slowing the overall rate of biodiversity loss. The field of synthetic biology, which is …
are not slowing the overall rate of biodiversity loss. The field of synthetic biology, which is …
Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae
A Cas9/guide RNA-based gene drive strain, AgNosCd-1, was developed to deliver
antiparasite effector molecules to the malaria vector mosquito, Anopheles gambiae. The …
antiparasite effector molecules to the malaria vector mosquito, Anopheles gambiae. The …
Study protocol for WHO and UNICEF estimates of global, regional, and national preterm birth rates for 2010 to 2019
Background Preterm birth is a leading cause of death among children under five years.
Previous estimates indicated global preterm birth rate of 10.6%(14.8 million neonates) in …
Previous estimates indicated global preterm birth rate of 10.6%(14.8 million neonates) in …
No time to waste—the ethical challenges created by CRISPR: CRISPR/Cas, being an efficient, simple, and cheap technology to edit the genome of any organism …
The term “CRISPR” has gained a lot of attention recently as a result of a debate among
scientists about the possibility of genetically modifying the human germ line and the ethical …
scientists about the possibility of genetically modifying the human germ line and the ethical …
[HTML][HTML] Pathway to deployment of gene drive mosquitoes as a potential biocontrol tool for elimination of malaria in sub-Saharan Africa: recommendations of a …
S James, FH Collins, PA Welkhoff… - The American journal …, 2018 - ncbi.nlm.nih.gov
Gene drive technology offers the promise for a high-impact, cost-effective, and durable
method to control malaria transmission that would make a significant contribution to …
method to control malaria transmission that would make a significant contribution to …
Advances and challenges in synthetic biology for mosquito control
Mosquito-borne illnesses represent a significant global health peril, resulting in
approximately one million fatalities annually. West Nile, dengue, Zika, and malaria are …
approximately one million fatalities annually. West Nile, dengue, Zika, and malaria are …
Promises and perils of gene drives: Navigating the communication of complex, post-normal science
In November of 2017, an interdisciplinary panel discussed the complexities of gene drive
applications as part of the third Sackler Colloquium on “The Science of Science …
applications as part of the third Sackler Colloquium on “The Science of Science …
Toward the definition of efficacy and safety criteria for advancing gene drive-modified mosquitoes to field testing
Mosquitoes containing gene drive systems are being developed as complementary tools to
prevent transmission of malaria and other mosquito-borne diseases. As with any new tool …
prevent transmission of malaria and other mosquito-borne diseases. As with any new tool …
Regulatory and policy considerations for the implementation of gene drive-modified mosquitoes to prevent malaria transmission
SL James, B Dass, H Quemada - Transgenic Research, 2023 - Springer
Gene drive-modified mosquitoes (GDMMs) are being developed as possible new tools to
prevent transmission of malaria and other mosquito-borne diseases. To date no GDMMs …
prevent transmission of malaria and other mosquito-borne diseases. To date no GDMMs …