Role of IFN-α in Rheumatoid Arthritis

CMA Lin, JD Isaacs, FAH Cooles - Current Rheumatology Reports, 2024 - Springer
Abstract Purpose of Review Type 1 interferons (IFN-I) are of increasing interest across a
wide range of autoimmune rheumatic diseases. Historically, research into their role in …

Role and therapeutic potential for targeting fibroblast growth factor 10/FGFR1 in relapsed rheumatoid arthritis

X Meng, Z Chen, T Li, Z Nie, H Han… - Arthritis & …, 2024 - Wiley Online Library
Objective Fibroblast‐like synoviocytes (FLSs) contribute to inflammation and joint damage in
rheumatoid arthritis (RA). However, the regulatory mechanisms of FLSs in relapse and …

An update on the roles of transcription factor Ets1 in autoimmune diseases

LA Garrett‐Sinha - WIREs Mechanisms of Disease, 2023 - Wiley Online Library
Transcription factors are crucial to regulate gene expression in immune cells and in other
cell types. In lymphocytes, there are a large number of different transcription factors that are …

A roadmap to the molecular human linking multiomics with population traits and diabetes subtypes

A Halama, S Zaghlool, G Thareja, S Kader… - Nature …, 2024 - nature.com
In-depth multiomic phenoty** provides molecular insights into complex physiological
processes and their pathologies. Here, we report on integrating 18 diverse deep molecular …

Interferon signature in systemic autoimmune diseases: what does it mean?

G Nocturne, X Mariette - RMD open, 2022 - rmdopen.bmj.com
The first description of the involvement of interferons (IFN) in systemic autoimmune diseases
(AID) dates back more than 40 years. 1 IFNs play a crucial role in numbers of immunological …

Gene signature of regulatory T Cells isolated from children with selective IgA deficiency and common variable immunodeficiency

M Rutkowska-Zapała, A Grabowska-Gurgul, M Lenart… - Cells, 2024 - mdpi.com
Selective IgA deficiency (SIgAD) is the most common form and common variable
immunodeficiency (CVID) is the most symptomatic form of predominant antibody deficiency …

[HTML][HTML] Deciphering molecular heterogeneity and dynamics of neural stem cells in human hippocampal development, aging, and injury

J Yao, S Dai, R Zhu, J Tan, Q Zhao, Y Yin, J Sun, X Du… - eLife, 2024 - elifesciences.org
While accumulated publications support the existence of neurogenesis in the adult human
hippocampus, the homeostasis and developmental potentials of neural stem cells (NSCs) …

Survivin promotes a glycolytic switch in CD4+ T cells by suppressing the transcription of PFKFB3 in rheumatoid arthritis

MC Erlandsson, KME Andersson, NY Oparina… - Iscience, 2022 - cell.com
In this study, we explore the role of nuclear survivin in maintaining the effector phenotype of
IFNγ-producing T cells acting through the transcriptional control of glucose utilization. High …

[HTML][HTML] Unraveling IFI44L's biofunction in human disease

J Du, H Luo, S Ye, H Zhang, Z Zheng… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Interferon-induced protein 44-like (IFI44L) is regarded as an immune-related gene and is a
member of interferon-stimulated genes (ISGs). They participate in network transduction, and …

Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury states

J Yao, S Dai, R Zhu, J Tan, Q Zhao, Y Yin, J Sun, X Du… - Elife, 2024 - elifesciences.org
While accumulated publications support the existence of neurogenesis in the adult human
hippocampus, the homeostasis and developmental potentials of neural stem cells (NSCs) …