The brain is the central and most complex organ in the nervous system, comprising billions
of neurons that constantly communicate through trillions of connections called synapses …

Early cognitive decline in patients with Alzheimer's (AD) is associated with quantifiable
structural and functional connectivity changes in the brain. AD dysregulation of Aβ and tau …

Age-related declines in cognitive fitness are associated with a reduction in autophagy, an
intracellular lysosomal catabolic process that regulates protein homeostasis and organelle …

Across systems, higher-order interactions between components govern emergent dynamics.
Here we tested whether contextual threat memory retrieval in mice relies on higher-order …

Cortical pathology contributes to chronic cognitive impairment of patients suffering from the
neuroinflammatory disease multiple sclerosis (MS). How such gray matter inflammation …

Background: The toxicity of microplastics (MPs) has attracted wide attention from
researchers. Previous studies have indicated that MPs produce toxic effects on a variety of …

The heavy metals lead (Pb), cadmium (Cd) and mercury (Hg) are common environmental
pollutants that can be detected simultaneously in blood, serum, and urine samples from the …

In the last two decades, microglia have emerged as key contributors to disease progression
in many neurological disorders, not only by exerting their classical immunological functions …

Aging is associated with loss of circadian immune responses and circadian gene
transcription in peripheral macrophages. Microglia, the resident macrophages of the brain …

Previous findings showed that in mice, complete knockout of activity-dependent
neuroprotective protein (ADNP) abolishes brain formation, while haploinsufficiency (Adnp+ …