The use of antibiotics has enabled the successful treatment of bacterial infections, saving the
lives and improving the health of many patients worldwide. However, the emergence and …

Antimicrobial resistance (AMR) and the associated morbidity and mortality due to bacterial
pathogens have been increasing globally to alarming levels. The World Health Organization …

The emergence and spread of antibiotic-resistant pathogens is a major public health issue,
which requires global action of an intersectoral nature. Multidrug-resistant (MDR) pathogens …

Clostridioides difficile is the most common cause of nosocomial antibiotic-associated
diarrhea, and is responsible for a spectrum of diseases characterized by high levels of …

Orally delivered antibiotics can reach the caecum and colon, and induce gut dysbiosis. Here
we show that the encapsulation of antibiotics in orally administered positively charged …

The emergence of multidrug-resistant bacteria demands innovations in the development of
new antibiotics. For decades, the glycopeptide antibiotic vancomycin has been considered …

Antimicrobial resistance (AMR) in Clostridioides difficile remains a significant threat to global
healthcare systems, not just for the treatment of C. difficile infection (CDI), but as a reservoir …

Anaerobic bacteria have pivotal roles in the microbiota of humans and they are significant
infectious agents involved in many pathological processes, both in immunocompetent and …

The species composition of the human gut microbiota is related to overall health, and a
healthy gut microbiome is crucial in maintaining colonization resistance against pathogens …

The 5-nitroimidazole drug metronidazole has remained the drug of choice in the treatment of
anaerobic infections, parasitic as well as bacterial, ever since its development in 1959. In …