Colon cancer affects both men and women and is the world's second most significant cause
of cancer-related mortality. Colon cancer death rates have risen worldwide due to the …

Y chromosome (ChrY), the male-specific sex chromosome, has been considered as a
genetic wasteland. Aging-related mosaic loss of ChrY (LOY) has been known for more than …

Micronuclei (MN), the small nucleus-like bodies separated from the primary nucleus, can
exist in cells with numerical and/or structural chromosomal aberrations in apparently normal …

One of the most curious findings emerged from genome-wide studies over the last decade
was that genetic mosaicism is a dominant feature of human ageing genomes. The clonal …

Simple Summary Non-canonical PCD is an important player in colon cancer cell suicide. It
influences colon cancer in many ways, such as through tumorigenesis, treatment, and …

In higher eukaryotes, sophisticate regulation of genome function requires all chromosomes
to be packed into a single nucleus. Micronucleus (MN), the dissociative nucleus-like …

Abstract Ethnopharmacological relevance Geranium wilfordii Maxim.(family Geraniaceae)
has been used as a multifunctional ethnomedicine in China for more than 600 years. There …

Patients with type 2 diabetes mellitus (T2DM) are associated with an elevated, but poorly
understood baseline of genomic instability (GIN). Expert panels are still debating on whether …

Preserving genome stability is essential to prevent aging and cancer. Dietary restriction (DR)
is the most reproducible non-pharmacological way to improve health and extend lifespan in …

Epidemiological studies have demonstrated that metformin (a cornerstone of diabetes
treatment) has anticancer activity, but the underlying mechanism remains elusive. We aimed …