Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia

S Tong, J Tu'uhevaha, R Hastie, F Brownfoot… - American journal of …, 2022 - Elsevier
There has been increasing research momentum to identify new therapeutic agents for the
prevention or treatment of preeclampsia, drugs that can affect the underlying disease …

Translation of mechanistic advances in preeclampsia to the clinic: long and winding road

R Thadhani, AS Cerdeira… - The FASEB Journal, 2024 - Wiley Online Library
As one of the leading causes of premature birth and maternal and infant mortality worldwide,
preeclampsia remains a major unmet public health challenge. Preeclampsia and related …

Novel approaches to combat preeclampsia: from new drugs to innovative delivery

N de Alwis, NK Binder, S Beard, J Tu'uhevaha, S Tong… - Placenta, 2020 - Elsevier
Preeclampsia is a complex disease affecting 2–8% of pregnancies worldwide. It poses
significant risk of maternal and perinatal morbidity and mortality. Despite the rising research …

Proton pump inhibitors and preeclampsia risk among 157 720 women: a Swedish population register–based cohort study

R Hastie, L Bergman, CA Cluver, A Wikman… - …, 2019 - ahajournals.org
Preeclampsia is a hypertensive disorder of pregnancy with a high rate of maternal and
neonatal morbidity and mortality. The only definite treatment is delivery. Preclinical …

Effects of apelin on neonatal brain neurogenesis in L-NAME-induced maternal preeclampsia

C Tomruk, C Şirin Tomruk, B Denizlioğlu… - Scientific Reports, 2024 - nature.com
The aim of this study was to investigate the possible protective effects of apelin, which is
known to have antioxidant and anti-inflammatory effects, on changes in neurogenesis in …

Novel therapeutic and diagnostic approaches for preeclampsia

M Vatish, VR Powys, AS Cerdeira - Current Opinion in …, 2023 - journals.lww.com
We provide an updated framework of the current approaches to define and diagnose
preeclampsia. Disease modifying therapies (in particular, targeting the angiogenic pathway) …

NLRP3 inhibition improves maternal hypertension, inflammation, and vascular dysfunction in response to placental ischemia

X Wang, OK Travis, CA Shields… - American Journal …, 2023 - journals.physiology.org
Preeclampsia (PE) is a pregnancy-specific hypertensive disorder with end-organ damage
that presents after 20 wk of gestation. PE pathophysiology often includes vascular …

[PDF][PDF] Treatment of reflux disease during pregnancy and lactation

Ü Dağlı, İH Kalkan - Turk J Gastroenterol, 2017 - cpdcentre.co.za
Gastroesophageal reflux disease (GERD) is frequently seen during pregnancy. In the
medical treatment of pregnant women with GERD, alginic acid and sucralfate can be used …

Receipt of proton-pump inhibitors during pregnancy and risk for preeclampsia

NA Bello, Y Huang, SK Syeda, JD Wright… - American journal of …, 2021 - thieme-connect.com
Objective This study aimed to determine whether receiving a proton-pump inhibitor (PPI)
prescription during pregnancy was associated with decreased risk for preeclampsia. Study …

[PDF][PDF] Study Effect of Esomeprazole on the Treatment of Preeclampsia in Pregnant Women: A Double-Blind Clinical Trial Study

F Zandvakili, S Zare, F Seydoshohadaei… - … Journal of Natural …, 2024 - researchgate.net
Background: Preeclampsia is one of the most serious complications of pregnancy, leading to
various maternal and fetal complications. Objectives: This study aimed to determine the …