A perspective on the prospective use of AI in protein structure prediction
AlphaFold2 (AF2) and RoseTTaFold (RF) have revolutionized structural biology, serving as
highly reliable and effective methods for predicting protein structures. This article explores …
highly reliable and effective methods for predicting protein structures. This article explores …
A review on the development of bacterial multi-epitope recombinant protein vaccines via reverse vaccinology
Y Li, MHR Farhan, X Yang, Y Guo, Y Sui, J Chu… - International Journal of …, 2024 - Elsevier
Bacterial vaccines play a crucial role in combating bacterial infectious diseases. Apart from
the prevention of disease, bacterial vaccines also help to reduce the mortality rates in …
the prevention of disease, bacterial vaccines also help to reduce the mortality rates in …
SARS-CoV-2 nsp3 and nsp4 are minimal constituents of a pore spanning replication organelle
L Zimmermann, X Zhao, J Makroczyova… - Nature …, 2023 - nature.com
Coronavirus replication is associated with the remodeling of cellular membranes, resulting
in the formation of double-membrane vesicles (DMVs). A DMV-spanning pore was identified …
in the formation of double-membrane vesicles (DMVs). A DMV-spanning pore was identified …
Temperature-dependent RNA editing in octopus extensively recodes the neural proteome
In poikilotherms, temperature changes challenge the integration of physiological function.
Within the complex nervous systems of the behaviorally sophisticated coleoid cephalopods …
Within the complex nervous systems of the behaviorally sophisticated coleoid cephalopods …
Genome-wide signatures of adaptation to extreme environments in red algae
The high temperature, acidity, and heavy metal-rich environments associated with hot
springs have a major impact on biological processes in resident cells. One group of …
springs have a major impact on biological processes in resident cells. One group of …
TmAlphaFold database: membrane localization and evaluation of AlphaFold2 predicted alpha-helical transmembrane protein structures
L Dobson, LI Szekeres, C Gerdán, T Langó… - Nucleic acids …, 2023 - academic.oup.com
AI-driven protein structure prediction, most notably AlphaFold2 (AF2) opens new frontiers for
almost all fields of structural biology. As traditional structure prediction methods for …
almost all fields of structural biology. As traditional structure prediction methods for …
TMbed: transmembrane proteins predicted through language model embeddings
M Bernhofer, B Rost - BMC bioinformatics, 2022 - Springer
Background Despite the immense importance of transmembrane proteins (TMP) for
molecular biology and medicine, experimental 3D structures for TMPs remain about 4–5 …
molecular biology and medicine, experimental 3D structures for TMPs remain about 4–5 …
Methyl-reducing methanogenesis by a thermophilic culture of Korarchaeia
Methanogenesis mediated by archaea is the main source of methane, a strong greenhouse
gas, and thus is critical for understanding Earth's climate dynamics. Recently, genes …
gas, and thus is critical for understanding Earth's climate dynamics. Recently, genes …
Insights into the Ecological Diversification of the Hymenochaetales based on Comparative Genomics and Phylogenomics With an Emphasis on Coltricia
To elucidate the genomic traits of ecological diversification in the Hymenochaetales, we
sequenced 15 new genomes, with attention to ectomycorrhizal (EcM) Coltricia species …
sequenced 15 new genomes, with attention to ectomycorrhizal (EcM) Coltricia species …
Macrocyclization and backbone rearrangement during RiPP biosynthesis by a SAM-dependent domain-of-unknown-function 692
The domain of unknown function 692 (DUF692) is an emerging family of post-translational
modification enzymes involved in the biosynthesis of ribosomally synthesized and post …
modification enzymes involved in the biosynthesis of ribosomally synthesized and post …