Regulatory T cells in the treatment of disease

A Sharabi, MG Tsokos, Y Ding, TR Malek… - Nature reviews Drug …, 2018 - nature.com
Regulatory T (Treg) cells suppress inflammation and regulate immune system activity. In
patients with systemic or organ-specific autoimmune diseases or those receiving …

Roles of cytokines and T cells in the pathogenesis of myasthenia gravis

A Uzawa, S Kuwabara, S Suzuki, T Imai… - Clinical & …, 2021 - academic.oup.com
Myasthenia gravis (MG) is characterized by muscle weakness and fatigue caused by the
presence of autoantibodies against the acetylcholine receptor (AChR) or the muscle-specific …

Vitamin D3 inhibits the proliferation of T helper cells, downregulate CD4+ T cell cytokines and upregulate inhibitory markers

V Sheikh, P Kasapoglu, A Zamani, Z Basiri… - Human immunology, 2018 - Elsevier
Abstract 1 α, 25-dihydroxyvitamin D3 (VitD3) has been suggested to have strong modulatory
properties in the immune system. Researchers in the present study primarily aimed to …

Advances in autoimmune myasthenia gravis management

S Wang, I Breskovska, S Gandhy… - Expert review of …, 2018 - Taylor & Francis
Introduction: Myasthenia gravis (MG) is an autoimmune neuromuscular disorder with no
cure and conventional treatments limited by significant adverse effects and variable benefit …

Immunopathogenesis in myasthenia gravis and neuromyelitis optica

Z Wang, Y Yan - Frontiers in immunology, 2017 - frontiersin.org
Myasthenia gravis (MG) and neuromyelitis optica (NMO) are autoimmune channelopathies
of the peripheral neuromuscular junction (NMJ) and central nervous system (CNS) that are …

An imbalance between regulatory T cells and T helper 17 cells in acetylcholine receptor–positive myasthenia gravis patients

JA Villegas, J Van Wassenhove… - Annals of the new …, 2018 - Wiley Online Library
A chronic autoimmune disease, myasthenia gravis (MG) is characterized in 85% of patients
by antibodies directed against the acetylcholine receptor (AChR) located at the …

Causal effect of vitamin D on myasthenia gravis: A two-sample Mendelian randomization study

Y Fan, H Huang, X Chen, Y Chen, X Zeng, F Lin… - Frontiers in …, 2023 - frontiersin.org
Introduction Observational studies suggest that vitamin D supplementation may be effective
in preventing myasthenia gravis (MG). However, the causal relationship between circulating …

Moderate exercise enhances the production of interferon-γ and interleukin-12 in peripheral blood mononuclear cells

A Zamani, I Salehi… - Immune …, 2017 - synapse.koreamed.org
The purpose of this study was to explore the effect of two months moderate exercise on
levels of IFN-γ, IL-12, IL-6 and IL-4 in serum and supernatants of in vitro mitogen-activated …

Estrogen receptor, inflammatory, and FOXO transcription factors regulate expression of myasthenia gravis-associated circulating microRNAs

AA Fiorillo, CR Heier, YF Huang, CB Tully… - Frontiers in …, 2020 - frontiersin.org
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate important
intracellular biological processes. In myasthenia gravis (MG), a disease-specific pattern of …

Decreased regulatory function of CD4+CD25+CD45RA+ T cells and impaired IL‐2 signalling pathway in patients with type 2 diabetes mellitus

V Sheikh, A Zamani… - Scandinavian …, 2018 - Wiley Online Library
In this study, the frequency and function of CD4+ CD25+ CD45RA+ regulatory T cells (Treg)
and intracellular IL‐2 signalling molecules in patients with type 2 diabetes mellitus (T2DM) …