Humans have a close phylogenetic relationship with nonhuman primates (NHPs) and share
many physiological parallels, such as highly similar immune systems, with them. Importantly …

Systemic chronic immune activation is considered today as the driving force of CD 4+ T‐cell
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disclose the variants of
concern (VOC) including Alpha (B. 1.1. 7), Beta (B. 1.351), Gamma (P1), Delta (B. 1.617. 2) …

In pathogenic simian immunodeficiency virus (SIV) and human immunodeficiency virus
(HIV) infections, the translocation of microbial products from the gastrointestinal (GI) tract to …

The pathogenesis of human and simian immunodeficiency viruses is characterized by CD4+
T cell depletion and chronic T cell activation, leading ultimately to AIDS. CD4+ T helper (TH) …

There is an intense interplay between HIV and the immune system, and the literature is
replete with studies describing various immunological phenomena associated with HIV …

The chronic phase of HIV infection is marked by pathological activation of the immune
system, the extent of which better predicts disease progression than either plasma viral load …

Many species of African nonhuman primates are naturally infected with simian
immunodeficiency viruses (SIVs) in the wild and in captivity. In contrast to HIV-infected …

Natural SIV infection of sooty mangabeys (SMs) is nonprogressive despite chronic virus
replication. Strikingly, it is characterized by low levels of immune activation, while …

Chronic immune activation and progression to AIDS are observed after SIV infection in
macaques but not in natural host primate species. To better understand this dichotomy, we …