Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes
The present review focuses on the evolution of proteins and the impact of amino acid
mutations on function from a structural perspective. Proteins evolve under the law of natural …
mutations on function from a structural perspective. Proteins evolve under the law of natural …
Propulsive nanomachines: the convergent evolution of archaella, flagella and cilia
Echoing the repeated convergent evolution of flight and vision in large eukaryotes,
propulsive swimming motility has evolved independently in microbes in each of the three …
propulsive swimming motility has evolved independently in microbes in each of the three …
Coevolutionary information, protein folding landscapes, and the thermodynamics of natural selection
The energy landscape used by nature over evolutionary timescales to select protein
sequences is essentially the same as the one that folds these sequences into functioning …
sequences is essentially the same as the one that folds these sequences into functioning …
Progress and challenges in predicting protein interfaces
The majority of biological processes are mediated via protein–protein interactions.
Determination of residues participating in such interactions improves our understanding of …
Determination of residues participating in such interactions improves our understanding of …
Evolutionary Rate Covariation Identifies New Members of a Protein Network Required for Drosophila melanogaster Female Post-Mating Responses
Seminal fluid proteins transferred from males to females during copulation are required for
full fertility and can exert dramatic effects on female physiology and behavior. In Drosophila …
full fertility and can exert dramatic effects on female physiology and behavior. In Drosophila …
Sequence evolution correlates with structural dynamics
Y Liu, I Bahar - Molecular biology and evolution, 2012 - academic.oup.com
Biochemical activity and core stability are essential properties of proteins, maintained
usually by conserved amino acids. Structural dynamics emerged in recent years as another …
usually by conserved amino acids. Structural dynamics emerged in recent years as another …
Evolution of the land plant exocyst complexes
F Cvrčková, M Grunt, R Bezvoda, M Hála… - Frontiers in plant …, 2012 - frontiersin.org
Exocyst is an evolutionarily conserved vesicle tethering complex functioning especially in
the last stage of exocytosis. Homologs of its eight canonical subunits–Sec3, Sec5, Sec6 …
the last stage of exocytosis. Homologs of its eight canonical subunits–Sec3, Sec5, Sec6 …
The evolution of gene duplicates in angiosperms and the impact of protein–protein interactions and the mechanism of duplication
Gene duplicates, generated through either whole genome duplication (WGD) or small-scale
duplication (SSD), are prominent in angiosperms and are believed to play an important role …
duplication (SSD), are prominent in angiosperms and are believed to play an important role …
Evolution of ribosomal protein network architectures
Y Timsit, G Sergeant-Perthuis, D Bennequin - Scientific reports, 2021 - nature.com
To perform an accurate protein synthesis, ribosomes accomplish complex tasks involving
the long-range communication between its functional centres such as the peptidyl transfer …
the long-range communication between its functional centres such as the peptidyl transfer …
Elucidating the druggable interface of protein− protein interactions using fragment docking and coevolutionary analysis
Protein− protein interactions play a central role in cellular function. Improving the
understanding of complex formation has many practical applications, including the rational …
understanding of complex formation has many practical applications, including the rational …