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The emergence and influence of internal states
Animal behavior is shaped by a variety of" internal states"—partially hidden variables that
profoundly shape perception, cognition, and action. The neural basis of internal states, such …
profoundly shape perception, cognition, and action. The neural basis of internal states, such …
The central nucleus of the amygdala and the construction of defensive modes across the threat-imminence continuum
In nature, animals display defensive behaviors that reflect the spatiotemporal distance of
threats. Laboratory-based paradigms that elicit specific defensive responses in rodents have …
threats. Laboratory-based paradigms that elicit specific defensive responses in rodents have …
Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice
D Chen, Q Lou, XJ Song, F Kang, A Liu… - Nature …, 2024 - nature.com
Anxiety-associated symptoms following acute stress usually become extinct gradually within
a period of time. However, the mechanisms underlying how individuals cope with stress to …
a period of time. However, the mechanisms underlying how individuals cope with stress to …
Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man
Post-traumatic stress disorder (PTSD) is a prevalent, debilitating and sometimes deadly
consequence of exposure to severe psychological trauma. Although effective treatments …
consequence of exposure to severe psychological trauma. Although effective treatments …
Neuronal circuits for fear and anxiety
Decades of research has identified the brain areas that are involved in fear, fear extinction,
anxiety and related defensive behaviours. Newly developed genetic and viral tools …
anxiety and related defensive behaviours. Newly developed genetic and viral tools …
Optogenetics: 10 years of microbial opsins in neuroscience
Over the past 10 years, the development and convergence of microbial opsin engineering,
modular genetic methods for cell-type targeting and optical strategies for guiding light …
modular genetic methods for cell-type targeting and optical strategies for guiding light …
Midbrain circuits for defensive behaviour
Survival in threatening situations depends on the selection and rapid execution of an
appropriate active or passive defensive response, yet the underlying brain circuitry is not …
appropriate active or passive defensive response, yet the underlying brain circuitry is not …
From circuits to behaviour in the amygdala
The amygdala has long been associated with emotion and motivation, playing an essential
part in processing both fearful and rewarding environmental stimuli. How can a single …
part in processing both fearful and rewarding environmental stimuli. How can a single …
Surviving threats: neural circuit and computational implications of a new taxonomy of defensive behaviour
Research on defensive behaviour in mammals has in recent years focused on elicited
reactions; however, organisms also make active choices when responding to danger. We …
reactions; however, organisms also make active choices when responding to danger. We …
Basolateral to central amygdala neural circuits for appetitive behaviors
Basolateral amygdala (BLA) principal cells are capable of driving and antagonizing
behaviors of opposing valence. BLA neurons project to the central amygdala (CeA), which …
behaviors of opposing valence. BLA neurons project to the central amygdala (CeA), which …