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[HTML][HTML] Colorectal cancer: a review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies
Simple Summary The high lethality of colorectal cancer (CRC) is anticipated to continue in
the following decades. Early-stage CRC is entirely treatable with surgery and adjuvant …
the following decades. Early-stage CRC is entirely treatable with surgery and adjuvant …
Genetic and biological hallmarks of colorectal cancer
Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …
tumors, and these insights have illuminated early detection, risk stratification, prevention …
[HTML][HTML] METTL3 inhibits antitumor immunity by targeting m6A-BHLHE41-CXCL1/CXCR2 axis to promote colorectal cancer
Background & Aims N 6-Methyladenosine (m 6 A) is the most prevalent RNA modification
and recognized as an important epitranscriptomic mechanism in colorectal cancer (CRC) …
and recognized as an important epitranscriptomic mechanism in colorectal cancer (CRC) …
Cytokine‐and chemokine‐induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy
Colorectal cancer (CRC) is a predominant life‐threatening cancer, with liver and peritoneal
metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor …
metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor …
Host–microbiota maladaptation in colorectal cancer
Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is
characterized by the accumulation of mutations and a dysregulated immune response. Up to …
characterized by the accumulation of mutations and a dysregulated immune response. Up to …
NF-κB, inflammation, immunity and cancer: coming of age
Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a
molecular lynchpin that links persistent infections and chronic inflammation to increased …
molecular lynchpin that links persistent infections and chronic inflammation to increased …
YAP/TAZ upstream signals and downstream responses
A Totaro, T Panciera, S Piccolo - Nature cell biology, 2018 - nature.com
Cell behaviour is strongly influenced by physical, mechanical contacts between cells and
their extracellular matrix. We review how the transcriptional regulators YAP and TAZ …
their extracellular matrix. We review how the transcriptional regulators YAP and TAZ …
The immunomodulatory role of matrix metalloproteinases in colitis-associated cancer
Matrix metalloproteinases (MMPs) are an important class of enzymes in the body that
function through the extracellular matrix (ECM). They are involved in diverse …
function through the extracellular matrix (ECM). They are involved in diverse …
The intestinal microbiota in colorectal cancer
Experimental evidence from the past years highlights a key role for the intestinal microbiota
in inflammatory and malignant gastrointestinal diseases. Diet exhibits a strong impact on …
in inflammatory and malignant gastrointestinal diseases. Diet exhibits a strong impact on …
KRAS-IRF2 axis drives immune suppression and immune therapy resistance in colorectal cancer
The biological functions and mechanisms of oncogenic KRAS G12D (KRAS∗) in resistance
to immune checkpoint blockade (ICB) therapy are not fully understood. We demonstrate that …
to immune checkpoint blockade (ICB) therapy are not fully understood. We demonstrate that …