Since their initial discovery in cats, low-threshold C-fiber mechanoreceptors have become a
central interest of scientists studying the affective aspects of touch. Their pursuit in humans …

Genetic pain loss includes congenital insensitivity to pain (CIP), hereditary sensory
neuropathies and, if autonomic nerves are involved, hereditary sensory and autonomic …

The versatility of somatosensation arises from heterogeneous dorsal root ganglion (DRG)
neurons. However, soma transcriptomes of individual human (h) DRG neurons—critical …

Loss-of-function mutations in Nav1. 7, a voltage-gated sodium channel, cause congenital
insensitivity to pain (CIP) in humans, demonstrating that Nav1. 7 is essential for the …

Affective touch is necessary for proper neurodevelopment and sociability. However, it
remains unclear how the neurons innervating the skin detect affective and social behaviors …

Low-threshold mechanosensory C-fibres, C-tactile afferents (CTs), respond optimally to
sensations associated with a human caress. Additionally, CT-stimulation activates brain …

The versatility of somatosensation arises from heterogenous human dorsal root ganglion
(DRG) neurons. The critical information to decipher their functions, ie, the soma …

Dorsal root ganglia (DRG) neurons have been well described for their role in driving both
acute and chronic pain. Although nerve injury is known to cause transcriptional …

Gain-of-function mutations in Scn9a, which encodes the peripheral sensory neuron-
enriched voltage-gated sodium channel Na v 1.7, cause paroxysmal extreme pain disorder …

Facial expressions are an increasingly used tool to assess emotional experience and
affective state during experimental procedures in animal models. Previous studies have …