Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Chemistry” on HDX MS. 1 That review covered HDX MS applications from January 2012
through June 2014 and described the publications in terms of sector, geography, and topic …

A yet unresolved challenge in structural biology is to quantify the conformational states of
proteins underpinning function. This challenge is particularly acute for membrane proteins …

SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 pandemic. Its
genome is translated into two large polyproteins subsequently cleaved by viral papain-like …

Hydrogen–Deuterium exchange mass spectrometry's (HDX-MS) utility in identifying and
characterizing protein–small molecule interaction sites has been established. The regions …

Atypical Chemokine Receptor 3 (ACKR3) belongs to the G protein-coupled receptor family
but it does not signal through G proteins. The structural properties that govern the functional …

Data produced by hydrogen-exchange monitoring experiments have been used in structural
studies of molecules for several decades. Despite uncertainties about the structural …

The big data concept is currently revolutionizing several fields of science including drug
discovery and development. While opening up new perspectives for better drug design and …

Secondary-active transporters catalyze the movement of myriad substances across all
cellular membranes, typically against opposing concentration gradients, and without …

Although computational structure prediction has had great successes in recent years, it
regularly fails to predict the interactions of large protein complexes with residue-level …