Copper is an essential trace element in biological systems, maintaining the activity of
enzymes and the function of transcription factors. However, at high concentrations, copper …

As an essential micronutrient, copper is required for a wide range of physiological processes
in virtually all cell types. Because the accumulation of intracellular copper can induce …

Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations
exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How …

Copper and other trace metals are essential for life. However, it is important that these
metals are present at the right amount in cells. Too little metal can impair the function of …

Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …

Although transition metals constitute less than 0.1% of the total mass within a human body,
they have a substantial impact on fundamental biological processes across all kingdoms of …

The mechanisms by which cells adapt to proteotoxic stress are largely unknown, but are key
to understanding how tumor cells, particularly in vivo, are largely resistant to proteasome …

Copper (Cu) is a vital element required for cellular growth and development; however, even
slight changes in its homeostasis might lead to severe toxicity and deleterious medical …

Copper, an essential micronutrient, controls multiple fundamental processes throughout all
forms of life, such as respiration, cell proliferation and neurotransmitter biosynthesis. High …

Copper is an essential micronutrient that plays a pivotal role in numerous physiological
processes in virtually all cell types. Nevertheless, the dysregulation of copper homeostasis …