Next-generation sequencing technologies have enabled a dramatic expansion of clinical
genetic testing both for inherited conditions and diseases such as cancer. Accurate variant …

Preclinical models that can accurately predict outcomes in the clinic are much sought after in
the field of cancer drug discovery and development. Existing models such as organoids and …

Histological artefacts in cryosectioned tissue can hinder rapid diagnostic assessments
during surgery. Formalin-fixed and paraffin-embedded (FFPE) tissue provides higher quality …

Purpose The survival benefit with adjuvant chemotherapy for patients with resected stage II-
III non–small-cell lung cancer (NSCLC) is modest. Efforts to develop prognostic or predictive …

In the late 19th century, formalin fixation with paraffin-embedding (FFPE) of tissues was
developed as a fixation and conservation method and is still used to this day in routine …

In chronic lymphocytic leukemia (CLL), TP53 gene defects, due to deletion of the 17p13
locus and/or mutation (s) within the TP53 gene, are associated with resistance to …

Neoantigens are newly formed peptides created from somatic mutations that are capable of
inducing tumor-specific T cell recognition. Recently, researchers and clinicians have …

Purpose Fresh-frozen (FF) tissue is the optimal source of DNA for whole-genome
sequencing (WGS) of cancer patients. However, it is not always available, limiting the …

A growing number of druggable targets and national initiatives for precision oncology
necessitate broad genomic profiling for many cancer patients. Whole exome sequencing …

Next-generation sequencing (NGS) technologies have come of age as preferred
technologies for screening of genomic variants of pathologic and therapeutic potential …