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The senescence-associated secretory phenotype and its physiological and pathological implications
Cellular senescence is a state of terminal growth arrest associated with the upregulation of
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …
Drug repurposing for cancer therapy
Y **" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …
Senescence and cancer—role and therapeutic opportunities
Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …
Cellular senescence and senolytics: the path to the clinic
Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …
disorders and diseases. One such process is cellular senescence, which entails a state of …
SenNet recommendations for detecting senescent cells in different tissues
Once considered a tissue culture-specific phenomenon, cellular senescence has now been
linked to various biological processes with both beneficial and detrimental roles in humans …
linked to various biological processes with both beneficial and detrimental roles in humans …
The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
Exploiting senescence for the treatment of cancer
L Wang, L Lankhorst, R Bernards - Nature Reviews Cancer, 2022 - nature.com
Senescence is a cellular response to a variety of stress signals that is characterized by a
stable withdrawal from the cell cycle and major changes in cell morphology and physiology …
stable withdrawal from the cell cycle and major changes in cell morphology and physiology …
Advances in PET imaging of cancer
J Schwenck, D Sonanini, JM Cotton… - Nature Reviews …, 2023 - nature.com
Molecular imaging has experienced enormous advancements in the areas of imaging
technology, imaging probe and contrast development, and data quality, as well as machine …
technology, imaging probe and contrast development, and data quality, as well as machine …
The metabolic roots of senescence: mechanisms and opportunities for intervention
CD Wiley, J Campisi - Nature metabolism, 2021 - nature.com
Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic
changes. Among these changes is the release of numerous biologically active molecules …
changes. Among these changes is the release of numerous biologically active molecules …