Nucleobase editors comprising nucleic acid programmable DNA binding proteins
2019-03-13 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
AAV delivery of nucleobase editors
DR Liu, JM Levy, WH Yeh - US Patent 11,306,324, 2022 - Google Patents
2018-02-22 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
Evolved cas9 proteins for gene editing
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that
are useful for engineering Cas9 and Cas9 variants that have increased activity on target …
are useful for engineering Cas9 and Cas9 variants that have increased activity on target …
Incorporation of unnatural amino acids into proteins using base editing
2022-08-22 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
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reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
Programmable cas9-recombinase fusion proteins and uses thereof
DR Liu, B Chaikind, JL Bessen - US Patent 11,661,590, 2023 - Google Patents
2019-02-25 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
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Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
2022-07-14 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
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reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE)
DR Liu, B Thuronyi, CG Wilson - US Patent 11,732,274, 2023 - Google Patents
The instant specification provides for evolved base editors which overcome deficiencies of
those in art (including increased efficiency and/or decreased requirement for specific …
those in art (including increased efficiency and/or decreased requirement for specific …
Cas9 proteins including ligand-dependent inteins
DR Liu, K Davis - US Patent 11,578,343, 2023 - Google Patents
2022-05-09 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
Switchable CAS9 nucleases and uses thereof
Some aspects of this disclosure provide compositions, meth ods, systems, and kits for
controlling the activity and/or improving the specificity of RNA-programmable endonu …
controlling the activity and/or improving the specificity of RNA-programmable endonu …
Uses of adenosine base editors
The disclosure provides methods and compositions for treating blood diseases/disorders,
such as sickle cell disease, hemochromatosis, hemophilia, and beta-thalassemia. For …
such as sickle cell disease, hemochromatosis, hemophilia, and beta-thalassemia. For …