Malignant gliomas are the most common malignant primary brain tumors and one of the
most challenging forms of cancers to treat. Despite advances in conventional treatment, the …

Radiation therapy plays an increasingly important role in cancer treatment. It can inhibit the
progression of various cancers through radiation-induced DNA breakage and reactive …

Anticancer agents that target both tumor cells and angiogenesis are of potential interest for
glioblastoma (GB) therapy. One such agent is sorafenib (SFN), a tyrosine kinase inhibitor …

Glioblastoma, the most common primary brain tumor in adults, is an incurable malignancy
with poor short-term survival and is typically treated with radiotherapy along with …

Purpose To establish the maximum tolerated dose of a 3-fraction hypofractionated
stereotactic reirradiation schedule when delivered with concomitant bevacizumab to treat …

Glioblastomas are grade IV brain tumors characterized by high aggressiveness and
invasiveness, giving patients a poor prognosis. We investigated the effects of the multi …

Despite relevant progress obtained by multimodal treatment, glioblastoma (GBM), the most
aggressive primary brain tumor, is still incurable. The most encouraging advancement of …

Background: Sorafenib (Sb) is a multiple kinase inhibitor targeting both tumour cell
proliferation and angiogenesis that may further act as a potent radiosensitizer by arresting …

Circumventing chemoresistance is crucial for effectively treating cancer including
glioblastoma, a lethal brain cancer. The gap junction protein connexin 43 (Cx43) renders …

Glioblastoma is the most common primary malignant tumor of the central nervous system,
with an annual incidence of 5.26 per 100000 people. The clinical outcome of standard …