Population aging is one of the most significant social changes of the twenty-first century. This
increase in longevity is associated with a higher prevalence of chronic diseases, further …

Hybrid imaging using PET/MRI has emerged as a platform for elucidating novel
neurobiology, molecular and functional changes in disease, and responses to physiological …

Trait anxiety has been associated with altered activity within corticolimbic pathways
connecting the amygdala and rostral anterior cingulate cortex (rACC), which receive rich …

While there is consistent evidence for increased presynaptic dopamine synthesis capacity in
the striatum of patients with schizophrenia during psychosis, it is unclear whether this also …

Introduction While increasing evidence points toward the benefits of musical activities in
promoting cognitive and emotional well-being in older adults, more longitudinal studies are …

The dorsal raphe nucleus (DRN) is one of the earliest targets of Alzheimer's disease-related
tau pathology and is a major source of brain serotonin. We used [18F] Fluoro-m-tyrosine …

Aging is associated with declines in multiple components of the dopamine system including
loss of dopamine-producing neurons, atrophy of the dopamine system's cortical targets, and …

Growth hormone secretagogue receptor 1a (GHSR1a), a member of the G protein-coupled
receptor (GPCR) family, is a functional receptor of ghrelin. The expression levels and …

Cognitive flexibility is an executive functioning skill that develops in childhood, and when
impaired, has transdiagnostic implications for psychiatric disorders. To identify how intrinsic …

Background Impaired cognitive flexibility has been implicated in the genetic basis of
obsessive-compulsive disorder (OCD). Recent endophenotype studies of OCD showed …