Controversies persist regarding the association between blood pressure (BP) and the risks
of cognitive impairment and dementia due to inconsistent definitions of BP exposure and …

The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …

Flow of cerebrospinal fluid (CSF) through perivascular spaces (PVSs) in the brain is
important for clearance of metabolic waste. Arterial pulsations are thought to drive flow, but …

As medical imaging enters its information era and presents rapidly increasing needs for big
data analytics, robust pooling and harmonization of imaging data across diverse cohorts …

Hypertension has emerged as a leading cause of age-related cognitive impairment. Long
known to be associated with dementia caused by vascular factors, hypertension has more …

Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit
studies of the relationships between the two major proteins deposited in this disease …

Cardiovascular disease (CVD) remains one of the leading causes of morbidity and mortality
in aging adults across the United States. Prior studies indicate that the presence of …

Executive summary Alzheimer's disease (AD) is the leading cause of dementia, and
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …

Background—Age-related dementia, most commonly caused by Alzheimer disease or
cerebrovascular factors (vascular dementia), is a major public health threat. Chronic arterial …

Importance Midlife vascular risk factors have been associated with late-life dementia.
Whether these risk factors directly contribute to brain amyloid deposition is less well …