Systemic arterial hypertension (referred to as hypertension herein) is a major risk factor of
mortality worldwide, and its importance is further emphasized in the context of the novel …

Cigarette smoking is the single most important risk factor for the development of
cardiovascular and pulmonary diseases (CVPD). Although cigarette smoking has been in …

The function of a cell is defined by its intrinsic characteristics and its niche: the tissue
microenvironment in which it dwells. Here we combine single-cell and spatial …

Background A potential association between the use of angiotensin-receptor blockers
(ARBs) and angiotensin-converting–enzyme (ACE) inhibitors and the risk of coronavirus …

Background Renin-angiotensin system (RAS) signaling and angiotensin-converting enzyme
2 (ACE2) have been implicated in the pathogenesis of acute respiratory distress syndrome …

A novel coronavirus disease, COVID-19, has created a global pandemic in 2020, posing an
enormous challenge to healthcare systems and affected communities. COVID-19 is caused …

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) associates with a considerable high rate of mortality and …

Rationale: Exogenous angiotensin II increases mean arterial pressure in patients with
catecholamine-resistant vasodilatory shock (CRVS). We hypothesized that renin …

Renin-angiotensin system (RAS) inhibitors (RASi)—widely prescribed for the treatment of
cardiovascular diseases—have considerable potential in oncology. The RAS plays a crucial …

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was first identified in
December 2019 as a novel respiratory pathogen and is the causative agent of Corona Virus …