Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior
pharmacological applications. Structurally, there are two types of five-membered triazoles: 1 …

Fungal infections are underestimated threats that affect over 1 billion people, and Candida
spp., Cryptococcus spp., and Aspergillus spp. are the 3 most fatal fungi. The treatment of …

The cytochrome P450 enzyme lanosterol 14α-demethylase (LDM) is the target of the azole
antifungals used widely in medicine and agriculture as prophylaxis or treatments of …

Infections caused by Candida species have been increasing in the last decades and can
result in local or systemic infections, with high morbidity and mortality. After Candida …

Following their extensive use, azole antifungals may enter the environment through the
discharge of domestic, industrial and hospital wastewaters, agricultural runoffs and as …

Emergence of fungal strains showing resistance to triazole drugs can make treatment of
fungal disease problematic. Triazole resistance can arise due to single mutations in the drug …

Candida and Cryptococcus affect millions of people yearly, being responsible for a wide
array of clinical presentations, including life‐threatening diseases. Interestingly, most human …

The global food supply has been facing increasing challenges during the first decades of the
21st century. Disease in plants is an important constraint to worldwide crop production …

Azole antifungals, known as demethylase inhibitors (DMIs), target sterol 14α-demethylase
(CYP51) in the ergosterol biosynthetic pathway of fungal pathogens of both plants and …

This study aimed to investigate the influence of tetraconazole and malathion, both used in
agricultural activities, on resistance to fluconazole, itraconazole and voriconazole in …