Although asthma has been considered as a single disease for years, recent studies have
increasingly focused on its heterogeneity. The characterization of this heterogeneity has …

Asthma, and severe asthma, in particular, is increasingly recognized as a heterogeneous
disease. While traditional views of asthma have centered around a childhood onset disease …

The European Position Paper on Rhinosinusitis and Nasal Polyps 2012 is the update of
similar evidence based position papers published in 2005 and 2007. The document …

BACKGROUND: Eosinophilic airway inflammation is heterogeneous in asthmatic patients.
We recently described a distinct subtype of asthma defined by the expression of genes …

Rationale: The mechanisms that underlie the pathogenesis of chronic rhinosinusitis without
nasal polyps (CRSsNP), chronic rhinosinusitis with nasal polyps (CRSwNP), and aspirin …

Matricellular proteins are involved in the crosstalk between cells and their environment and
thus play an important role in allergic and inflammatory reactions. Periostin, a matricellular …

We found for the first time that IL-4 and IL-13, signature type 2 cytokines, are able to induce
periostin expression. We and others have subsequently shown that periostin is highly …

Nonsteroidal anti‐inflammatory drugs (NSAIDs), the medications most commonly used for
treating pain and inflammation, are the main triggers of drug hypersensitivity reactions. The …

Periostin is a matricellular protein as well as an extracellular matrix (ECM) protein belonging
to the fasciclin family. Periostin plays important roles as a matricellular protein in the setting …

Discerning the genetics and epigenetics of chronic rhinosinusitis (CRS) may optimize
outcomes through early diagnostics, personalized and novel therapeutics, and early …