The high heterogeneity of psychiatric disorders leads to a lack of diagnostic precision.
Therefore, the search of biomarkers is a fundamental aspect in psychiatry to reach a more …

Cannabis has long been known to produce cognitive and emotional effects. Research has
shown that cannabinoid drugs produce these effects by driving the brain's endogenous …

Evidence for the involvement of the endocannabinoid system (ECS) in anxiety and fear has
been accumulated, providing leads for novel therapeutic approaches. In anxiety, a …

Post‐traumatic stress disorder (PTSD), a diagnosis that may follow the experience of trauma,
has multiple symptomatic phenotypes. Generally, individuals with PTSD display symptoms …

Anandamide is a lipid mediator that acts as an endogenous ligand of CB1 receptors. These
receptors are also the primary molecular target responsible for the pharmacological effects …

Background: Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme that
hydrolyzes the endocannabinoid anandamide and related amidated signaling lipids …

The endogenous cannabinoid system is an important regulatory system involved in
physiological homeostasis. Endocannabinoid signaling is known to modulate neural …

Dysregulation in signaling of the endocannabinoid 2-arachidonoylglycerol (2-AG) is
implicated in hyperresponsiveness to stress. We hypothesized that blockade of …

The central endocannabinoid system is a neuroactive lipid signalling system in the brain
which acts to control neurotransmitter release. The expression patterns of this system …

The midbrain dorsal periaqueductal gray (dPAG) has an important role in orchestrating
anxiety-and panic-related responses. Given the cellular and behavioral evidence …