Imagining the future of optical microscopy: everything, everywhere, all at once

H Balasubramanian, CM Hobson, TL Chew… - Communications …, 2023 - nature.com
The optical microscope has revolutionized biology since at least the 17th Century. Since
then, it has progressed from a largely observational tool to a powerful bioanalytical platform …

A growing battlefield in the war against biofilm-induced antimicrobial resistance: insights from reviews on antibiotic resistance

L Pai, S Patil, S Liu, F Wen - Frontiers in Cellular and Infection …, 2023 - frontiersin.org
Biofilms are a common survival strategy employed by bacteria in healthcare settings, which
enhances their resistance to antimicrobial and biocidal agents making infections difficult to …

Deep learning-based virtual staining, segmentation, and classification in label-free photoacoustic histology of human specimens

C Yoon, E Park, S Misra, JY Kim, JW Baik… - Light: Science & …, 2024 - nature.com
In pathological diagnostics, histological images highlight the oncological features of excised
specimens, but they require laborious and costly staining procedures. Despite recent …

Titanium: sapphire-on-insulator integrated lasers and amplifiers

J Yang, K Van Gasse, DM Lukin, MA Guidry, GH Ahn… - Nature, 2024 - nature.com
Abstract Titanium: sapphire (Ti: sapphire) lasers have been essential for advancing
fundamental research and technological applications, including the development of the …

Quantitative phase imaging endoscopy with a metalens

A Shanker, JE Fröch, S Mukherjee… - Light: Science & …, 2024 - nature.com
Quantitative phase imaging (QPI) recovers the exact wavefront of light from intensity
measurements. Topographical and optical density maps of translucent microscopic bodies …

Engineering the future of 3D pathology

JTC Liu, SSL Chow, R Colling… - The Journal of …, 2024 - Wiley Online Library
In recent years, technological advances in tissue preparation, high‐throughput volumetric
microscopy, and computational infrastructure have enabled rapid developments in …

Robotic-OCT guided inspection and microsurgery of monolithic storage devices

B He, Y Zhang, L Zhao, Z Sun, X Hu, Y Kang… - Nature …, 2023 - nature.com
Data recovery from monolithic storage devices (MSDs) is in high demand for legal or
business purposes. However, the conventional data recovery methods are destructive …

Full-field optical coherence microscopy enables high-resolution label-free imaging of the dynamics of live mouse oocytes and early embryos

S Morawiec, A Ajduk, P Stremplewski… - Communications …, 2024 - nature.com
High quality label-free imaging of oocytes and early embryos is essential for accurate
assessment of their developmental potential, a key element of assisted reproduction …

Eye-brain connections revealed by multimodal retinal and brain imaging genetics

B Zhao, Y Li, Z Fan, Z Wu, J Shu, X Yang… - Nature …, 2024 - nature.com
The retina, an anatomical extension of the brain, forms physiological connections with the
visual cortex of the brain. Although retinal structures offer a unique opportunity to assess …

Analysis of 3D pathology samples using weakly supervised AI

AH Song, M Williams, DFK Williamson, SSL Chow… - Cell, 2024 - cell.com
Human tissue, which is inherently three-dimensional (3D), is traditionally examined through
standard-of-care histopathology as limited two-dimensional (2D) cross-sections that can …