Membrane fission is a fundamental process in the regulation and remodelling of cell
membranes. Dynamin, a large GTPase, mediates membrane fission by assembling around …

Elucidating protein functions and molecular organisation requires to localise precisely single
or aggregated molecules and analyse their spatial distributions. We develop a statistical …

Clathrin-mediated endocytosis is the primary pathway for receptor and cargo internalization
in eukaryotic cells. It is characterized by a polyhedral clathrin lattice that coats budding …

Clathrin-mediated endocytosis (CME) internalizes plasma membrane by resha** small
regions of the cell surface into spherical vesicles. The key mechanistic question of how coat …

Clathrin-coated vesicles form by rapid assembly of discrete coat constituents into a cargo-
sorting lattice. How the sequential phases of coat construction are choreographed is …

Rab-GTPases and their interacting partners are key regulators of secretory vesicle
trafficking, docking, and fusion to the plasma membrane in neurons and neuroendocrine …

The plasma membrane separates a cell from its external environment. All materials and
signals that enter or leave the cell must cross this hydrophobic barrier. Understanding the …

Cellular communication is regulated at the plasma membrane by the interactions of receptor,
adhesion, signaling, exocytic, and endocytic proteins. Yet, the composition and control of …

How and when the dozens of molecules that control exocytosis assemble in living cells to
regulate the fusion of a vesicle with the plasma membrane is unknown. Here we image with …

The plasma membrane is a highly compartmentalized, dynamic material and this
organization is essential for a wide variety of cellular processes. Nanoscale domains allow …