Localization, tissue biology and T cell state—implications for cancer immunotherapy
Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-
dependent killers, which requires them to physically be within the tissue of interest to kill …
dependent killers, which requires them to physically be within the tissue of interest to kill …
How chemokines organize the tumour microenvironment
For our immune system to contain or eliminate malignant solid tumours, both myeloid and
lymphoid haematopoietic cells must not only extravasate from the bloodstream into the …
lymphoid haematopoietic cells must not only extravasate from the bloodstream into the …
Multiplexed imaging mass cytometry of the chemokine milieus in melanoma characterizes features of the response to immunotherapy
Intratumoral immune cells are crucial for tumor control and antitumor responses during
immunotherapy. Immune cell trafficking into tumors is mediated by binding of specific …
immunotherapy. Immune cell trafficking into tumors is mediated by binding of specific …
A human autoimmune organoid model reveals IL-7 function in coeliac disease
In vitro models of autoimmunity are constrained by an inability to culture affected epithelium
alongside the complex tissue-resident immune microenvironment. Coeliac disease (CeD) is …
alongside the complex tissue-resident immune microenvironment. Coeliac disease (CeD) is …
[HTML][HTML] GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma
Background Aggressive primary brain tumors such as glioblastoma are uniquely
challenging to treat. The intracranial location poses barriers to therapy, and the potential for …
challenging to treat. The intracranial location poses barriers to therapy, and the potential for …
Interpretable and context-free deconvolution of multi-scale whole transcriptomic data with UniCell deconvolve
Abstract We introduce UniCell: Deconvolve Base (UCDBase), a pre-trained, interpretable,
deep learning model to deconvolve cell type fractions and predict cell identity across Spatial …
deep learning model to deconvolve cell type fractions and predict cell identity across Spatial …
Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology
IJ Hartnell, D Woodhouse, W Jasper, L Mason… - Brain, 2024 - academic.oup.com
Frontotemporal lobar degeneration with tau (FTLD-tau) is a group of tauopathies that
underlie∼ 50% of FTLD cases. Identification of genetic risk variants related to …
underlie∼ 50% of FTLD cases. Identification of genetic risk variants related to …
T cell-mediated additive cytotoxicity–death by multiple bullets
Immune effector cells, including cytotoxic T cells (CTLs), induce apoptosis and eliminate
target cells by direct cell–cell contacts. In vivo, CTLs fail to efficiently kill solid tumor cells by …
target cells by direct cell–cell contacts. In vivo, CTLs fail to efficiently kill solid tumor cells by …
High resolution microfluidic assay and probabilistic modeling reveal cooperation between T cells in tumor killing
Cytotoxic T cells are important components of natural anti-tumor immunity and are
harnessed in tumor immunotherapies. Immune responses to tumors and immune therapy …
harnessed in tumor immunotherapies. Immune responses to tumors and immune therapy …
[HTML][HTML] Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival
Background The composition of the tumor immune microenvironment (TIME) associated with
good prognosis generally also predicts the success of immunotherapy, and both entail the …
good prognosis generally also predicts the success of immunotherapy, and both entail the …