Neuroblastoma is a tumour derived from primitive cells of the sympathetic nervous system
and is the most common solid tumour in childhood. Interestingly, most infants experience …

PURPOSE AND RESULTS: Neuroblastoma, the most common solid extracranial neoplasm
in children, is remarkable for its clinical heterogeneity. Complex patterns of genetic …

The proto‐oncogene MYCN is often amplified in human neuroblastomas. The assumption
that the amplification contributes to tumorigenesis has never been tested directly. We have …

We describe a gene encoding p73, a protein that shares considerable homology with the
tumor suppressor p53. p73 maps to 1p36, a region frequently deleted in neuroblastoma and …

Caspase 8 is a cysteine protease regulated in both a death-receptor-dependent and-
independent manner during apoptosis. Here, we report that the gene for caspase 8 is …

The transforming growth factor-β (TGF-β) superfamily contains a variety of growth factors
which all share common sequence elements and structural motifs. These proteins are …

Neuroblastoma is an embryonal malignancy of the sympathetic nervous system.
Spontaneous regression and differentiation of neuroblastoma is observed in a subset of …

Cancer gene discovery has relied extensively on analyzing tumors for gains and losses to
reveal the location of oncogenes and tumor suppressor genes, respectively. Deletions of …

The discovery that cancer can be governed above and beyond the level of our DNA
presents a new era for designing therapies that reverse the epigenetic state of a tumour cell …

Loss of 1p36 heterozygosity commonly occurs with MYCN amplification in neuroblastoma
tumors, and both are associated with an aggressive phenotype. Database searches …