Genetic dissection of complex traits

ES Lander, NJ Schork - Focus, 2006 - psychiatryonline.org
Medical genetics was revolutionized during the 1980s by the application of genetic map**
to locate the genes responsible for simple Mendelian diseases. Most diseases and traits …

Map** and analysis of quantitative trait loci in experimental populations

RW Doerge - Nature Reviews Genetics, 2002 - nature.com
Simple statistical methods for the study of quantitative trait loci (QTL), such as analysis of
variance, have given way to methods that involve several markers and high-resolution …

[КНИГА][B] Statistical genomics: linkage, map**, and QTL analysis

BH Liu - 2017 - taylorfrancis.com
Statistical Genomics: Linkage, Map**, and QTL Analysis Page 1 Page 2 Statistical Genomics
Linkage, Map**, and QTL Analysis CRCPress Ben Hui Liu Boca Raton London New York …

Permutation tests for multiple loci affecting a quantitative character

RW Doerge, GA Churchill - Genetics, 1996 - academic.oup.com
The problem of detecting minor quantitative trait loci (QTL) responsible for genetic variation
not explained by major QTL is of importance in the complete dissection of quantitative …

A simple method to calculate resolving power and confidence interval of QTL map location

A Darvasi, M Soller - Behavior genetics, 1997 - Springer
Abstract “Resolving power” is defined as the 95% confidence interval for quantitative trait
locus (QTL) map location that would be obtained when scoring an infinite number of markers …

DNA markers and plant breeding programs

M Lee - Advances in agronomy, 1995 - Elsevier
Publisher Summary On a worldwide basis, plant breeding has been one of the most
successful technologies developed in modern agriculture: its methods are opportunistic and …

A simple correction for multiple comparisons in interval map** genome scans

JM Cheverud - Heredity, 2001 - nature.com
Several approaches have been proposed to correct point-wise significance thresholds used
in interval-map** genome scans. A method for significance threshold correction based on …

Confidence intervals in QTL map** by bootstrap**

PM Visscher, R Thompson, CS Haley - Genetics, 1996 - academic.oup.com
The determination of empirical confidence intervals for the location of quantitative trait loci
(QTLs) was investigated using simulation. Empirical confidence intervals were calculated …

Statistical methods for map** quantitative trait loci from a dense set of markers

J Dupuis, D Siegmund - Genetics, 1999 - academic.oup.com
Lander and Botstein introduced statistical methods for searching an entire genome for
quantitative trait loci (QTL) in experimental organisms, with emphasis on a backcross design …

LOD significance thresholds for QTL analysis in experimental populations of diploid species

JW Van Ooijen - Heredity, 1999 - nature.com
Linkage analysis with molecular genetic markers is a very powerful tool in the biological
research of quantitative traits. The lack of an easy way to know what areas of the genome …