The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …

The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …

Recently researchers proposed the term 'Type-3-Diabetes' for Alzheimer's disease (ad)
because of the shared molecular and cellular features among Type-1-Diabetes, Type-2 …

The regulation of oxidative stress is an important factor in both tumour development and
responses to anticancer therapies. Many signalling pathways that are linked to …

Transcription factors of the forkhead box, class O (FoxO) family are important regulators of
the cellular stress response and promote the cellular antioxidant defense. On one hand …

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR)
signalling pathway is hyperactivated or altered in many cancer types and regulates a broad …

Mammalian target of rapamycin (mTOR) is a highly conserved Serine/Threonine (Ser/Thr)
protein kinase, which belongs to phosphatidylinositol-3-kinase-related kinase (PIKK) protein …

Aging happens to all of us as we live. Thanks to the improved living standard and discovery
of life-saving medicines, our life expectancy has increased substantially across the world in …

FOXO transcription factors are conserved regulators of longevity downstream of insulin
signaling. These transcription factors integrate signals emanating from nutrient deprivation …

Over the past two decades, our understanding of phospoinositide 3-kinases (PI3Ks) has
progressed from the identification of an enzymatic activity associated with growth factors …