Fluid control structures in microfluidic devices

RA Mathies, WH Grover, A Skelley, E Lagally… - US Patent …, 2008 - Google Patents
Methods and apparatus for implementing microfluidic analysis devices are provided. A
monolithic elastomer membrane associated with an integrated pneumatic manifold allows …

Microfabricated integrated DNA analysis system

RA Mathies, R Blazej, C Liu, P Kumaresan… - US Patent …, 2010 - Google Patents
Methods and apparatus for genome analysis are provided. A microfabricated structure
including a microfluidic distribu tion channel is configured to distribute microreactor …

Inline-injection microdevice and microfabricated integrated DNA analysis system using same

RA Mathies, R Blazej, P Kumaresan - US Patent 8,841,116, 2014 - Google Patents
Methods and microfluidic circuitry for inline injection of nucleic acids for capillary
electrophoresis analysis are provided. According to various embodiments, microfabricated …

Nucleic acid amplification using microfluidic devices

MM Enzelberger, CL Hansen, J Liu, SR Quake… - US Patent …, 2010 - Google Patents
The present invention provides microfluidic devices and methods using the same in various
types of thermal cycling reactions. Certaom devices include a rotary microfluidic channel …

Microfluidic devices and methods of using same

L McBride, M Unger, M Lucero, HR Nassef… - US Patent …, 2010 - Google Patents
(57) ABSTRACT A variety of elastomeric-based microfluidic devices and methods for using
and manufacturing such devices are pro vided. Certain of the devices have arrays of …

Microfluidic nucleic acid analysis

JW Hong, V Studer, WF Anderson, SR Quake… - US Patent …, 2014 - Google Patents
Nucleic acid from cells and viruses sampled from a variety of environments may puri? ed
and expressed utilizing micro? u idic techniques. In accordance With one embodiment of the …

Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions

RA Mathies, P Kumaresan, C Yang… - US Patent 8,454,906, 2013 - Google Patents
Provided are microfluidic designs and methods for rapid gen eration of monodisperse
nanoliter Volume droplets of reagent/target (eg, molecule or cell) mix in emulsion oil. The …

Fluidic devices with diaphragm valves

II Blaga, SB Jovanovich, B Kobrin… - US Patent …, 2013 - Google Patents
The fluidic devices of this invention comprise at least one or a plurality of fluidic conduits in
which fluid flow is con trolled by, for example, on-device diaphragm valves and pumps …

Microfluidic device and methods of using same

L McBride, M Lucero, M Unger, HR Nassef… - US Patent …, 2010 - Google Patents
A variety of elastomeric-based microfluidic devices and methods for using and
manufacturing such devices are provided. Certain of the devices have arrays of reaction …

Microfluidic devices and methods of using same

M Unger, J Huang, E Quan - US Patent 7,476,363, 2009 - Google Patents
4,585,209 4,662,710 4.675, 300 4,786,165 4,797.842 4,876.504 4,898,582 4,908,112
4,936.465 4,963,498 4,965,743 4,992,312 5,032,381 5,085,562 5,088,515 5,096,388 …