When Szent-Györgyi called water the “matrix of life”, 1 he was echoing an old sentiment.
Paracelsus in the 16th century said that “water was the matrix of the world and of all its …

This is a review of atomic pair distribution function (PDF) analysis as applied to the study of
molecular materials. The PDF method is a powerful approach to study short-and …

The liquid structure of the archetypal Deep Eutectic Solvent (DES) reline, a 1: 2 molar
mixture of choline chloride and urea, has been determined at 303 K. This is the first reported …

Szent-Győrgi called water the “matrix of life” and claimed that there was no life without it.
This statement is true, as far as we know, on our planet, but it is not clear whether it must …

Proteins are marginally stable, and the folding/unfolding equilibrium of proteins in aqueous
solution can easily be altered by the addition of small organic molecules known as …

The mechanism of denaturation of proteins by urea is explored by using all-atom
microseconds molecular dynamics simulations of hen lysozyme generated on BlueGene/L …

The mechanism by which urea and guanidinium destabilize protein structure is
controversial. We tested the possibility that these denaturants form hydrogen bonds with …

Little is presently known about the unique nanostructure of deep eutectic solvents (DES).
The order of the liquid–solid phase transition is contended and whether DES-water mixtures …

Though urea is commonly used to denature proteins, the molecular mechanism of its
denaturing ability is still a subject of considerable debate. Previous molecular dynamics …

In the current work, an experimental and theoretical study is performed on the urea-water
mixtures by using non-covalent interactions (NCI) and reduced density gradient (RDG) …