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Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications
Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying
pathobiology of COVID-19 will support the design of rational treatments targeting the life …
pathobiology of COVID-19 will support the design of rational treatments targeting the life …
Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation
Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a
new era for disease modeling and drug discovery. Over the past decade, significant …
new era for disease modeling and drug discovery. Over the past decade, significant …
[HTML][HTML] Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant
We identified an emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples …
variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples …
Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation
We identified a novel SARS-CoV-2 variant by viral whole-genome sequencing of 2,172
nasal/nasopharyngeal swab samples from 44 counties in California. Named B. 1.427/B …
nasal/nasopharyngeal swab samples from 44 counties in California. Named B. 1.427/B …
Human organoid models to study SARS-CoV-2 infection
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
On the whereabouts of SARS-CoV-2 in the human body: A systematic review
Since SARS-CoV-2 appeared in the human population, the scientific community has
scrambled to gather as much information as possible to find good strategies for the …
scrambled to gather as much information as possible to find good strategies for the …
Severely low testosterone in males with COVID‐19: a case‐control study
Background Circulating androgens could have a relevant pathobiological role in clinical
outcomes in men with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …
outcomes in men with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …
[HTML][HTML] Induced pluripotent stem cells (iPSCs)—roles in regenerative therapies, disease modelling and drug screening
The discovery of induced pluripotent stem cells (iPSCs) has made an invaluable contribution
to the field of regenerative medicine, paving way for identifying the true potential of human …
to the field of regenerative medicine, paving way for identifying the true potential of human …
SARS-CoV-2 infection and multi-organ system damage: A review
The SARS-CoV-2 infection causes COVID-19, which has affected approximately six hundred
million people globally as of 8 2022. Organs and cells harboring angiotensin-converting …
million people globally as of 8 2022. Organs and cells harboring angiotensin-converting …
ACE2: the molecular doorway to SARS-CoV-2
The angiotensin-converting enzyme 2 (ACE2) is the host functional receptor for the new
virus SARS-CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 72 different …
virus SARS-CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 72 different …