For several decades there has been accumulating evidence implicating type I interferons
(IFNs) as key elements of the immune response. Therapeutic approaches incorporating …

Cytokines play crucial roles in orchestrating complex multicellular interactions between
pancreatic β cells and immune cells in the development of type 1 diabetes (T1D) and are …

Abstract Type 1 diabetes (T1D) is an autoimmune disease in which immune cells destroy
insulin-producing beta cells. The aetiology of this complex disease is dependent on the …

Previous results indicate the presence of an interferon (IFN) signature in type 1 diabetes
(T1D), capable of inducing chronic inflammation and compromising b cell function. Here, we …

Previous studies have revealed heterogeneity in the progression to clinical type 1 diabetes
in children who develop islet-specific antibodies either to insulin (IAA) or glutamic acid …

IFNα is a cytokine essential to a vast array of immunologic processes. Its induction early in
the innate immune response provides a priming mechanism that orchestrates numerous …

Immune checkpoints (ICs), also referred to as co-inhibitory receptors (IRs), are essential for
regulating immune cell function to maintain tolerance and prevent autoimmunity. IRs, such …

Rationale: Increased endothelial permeability and defective repair are the hallmarks of
several vascular diseases, including acute lung injury. However, little is known about the …

Co-inhibitory receptors (IRs) are molecules that protect host against autoimmune reactions
and maintain peripheral self-tolerance, playing an essential role in maintaining immune …

Type 1 diabetes is an insulin-dependent, autoimmune disease where the pancreatic β cells
are destroyed resulting in hyperglycemia. This multifactorial disease involves multiple …