Microtubules have fundamental roles in many essential biological processes, including cell
division and intracellular transport. They assemble and disassemble from their two ends …

Mitotic spindle orientation is essential for cell fate decisions, epithelial maintenance, and
tissue morphogenesis. In most animal cell types, the dynein motor complex is anchored at …

The study of protein localisation has greatly benefited from high-throughput methods
utilising cellular fractionation and proteomic profiling. Hyperplexed Localisation of Organelle …

Gibbons are small arboreal apes that display an accelerated rate of evolutionary
chromosomal rearrangement and occupy a key node in the primate phylogeny between Old …

Classical microtubule‐associated proteins (MAPs) were originally identified based on their
co‐purification with microtubules assembled from mammalian brain lysate. They have since …

ABSTRACT Interferon stimulated gene 15 (ISG15) is an ubiquitin-like protein whose
expression and conjugation to targets (ISGylation) is induced by infection, interferon (IFN)-α …

INTRODUCTION When an egg is fertilized by a sperm, the chromosomes of the mother and
the father become united, and a genetically unique embryo starts to form. A healthy embryo …

Enhanced expression of the cancer stem cell (CSC) marker, CD133, is closely associated
with a higher rate of tumor formation and poor prognosis in hepatocellular carcinoma (HCC) …

To position the mitotic spindle within the cell, dynamic plus ends of astral microtubules are
pulled by membrane-associated cortical force-generating machinery. However, in contrast to …

In any mitotic cell, the orientation of the mitotic spindle determines the orientation of the
cleavage plane and therefore the position of the two daughter cells. When combined with …