P53 is a transcription factor highly inducible by many stress signals such as DNA damage,
oncogene activation, and nutrient deprivation. Cell-cycle arrest and apoptosis are the most …

In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

The ability of p53 to induce apoptosis plays an important role in tumor suppression. Here,
we describe a previously unknown posttranslational modification of the DNA-binding …

The tumor suppressor protein p53 is inactivated by mutation in about half of all human
cancers. Most mutations are located in the DNA-binding domain of the protein. It is …

The DNA-binding domain of the tumor suppressor p53 is inactivated by mutation in≈ 50% of
human cancers. We have solved high-resolution crystal structures of several oncogenic …

The maintenance of genome integrity is essential for any organism survival and for the
inheritance of traits to offspring. To the purpose, cells have developed a complex DNA repair …

Protein-protein interaction networks provide a global picture of cellular function and
biological processes. Some proteins act as hub proteins, highly connected to others …

We investigate the structural properties of hubs that enable them to interact with several
partners in protein–protein interaction networks. We find that hubs have more observed and …

Hubs are proteins with a large number of interactions in a protein-protein interaction
network. They are the principal agents in the interaction network and affect its function and …

Proteins are involved in various equilibria that play a major role in their activity or regulation.
The design of molecules that shift such equilibria is of great therapeutic potential. This fact …