A causal role for hyperinsulinemia in obesity

NM Templeman, S Skovsø, MM Page… - Journal of …, 2017 - joe.bioscientifica.com
Insulin modulates the biochemical pathways controlling lipid uptake, lipolysis and
lipogenesis at multiple levels. Elevated insulin levels are associated with obesity, and …

Mild suppression of hyperinsulinemia to treat obesity and insulin resistance

MM Page, JD Johnson - Trends in Endocrinology & Metabolism, 2018 - cell.com
Insulin plays roles in lipid uptake, lipolysis, and lipogenesis, in addition to controlling blood
glucose levels. Excessive circulating insulin is associated with adipose tissue expansion …

Combination of high-fat/high-fructose diet and low-dose streptozotocin to model long-term type-2 diabetes complications

DA Barrière, C Noll, G Roussy, F Lizotte, A Kessai… - Scientific Reports, 2018 - nature.com
The epidemic of type 2 diabetes mellitus (T2DM) is fueled by added fructose consumption.
Here, we thus combined high-fat/high-fructose diet, with multiple low-dose injections of …

The gut microbiome and type 2 diabetes status in the Multiethnic Cohort

G Maskarinec, P Raquinio, BS Kristal, VW Setiawan… - Plos one, 2021 - journals.plos.org
Background The gut microbiome may play a role in inflammation associated with type 2
diabetes (T2D) development. This cross-sectional study examined its relation with glycemic …

Diabetes pharmacotherapy and effects on the musculoskeletal system

E Kalaitzoglou, JL Fowlkes, I Popescu… - … research and reviews, 2019 - Wiley Online Library
Persons with type 1 or type 2 diabetes have a significantly higher fracture risk than age‐
matched persons without diabetes, attributed to disease‐specific deficits in the …

[HTML][HTML] From an apple to a pear: moving fat around for reversing insulin resistance

M Alser, MA Elrayess - … Journal of Environmental Research and Public …, 2022 - mdpi.com
Type 2 diabetes (T2D) is a chronic condition where the body is resistant to insulin, leading to
an elevated blood glucose state. Obesity is a main factor leading to T2D. Many clinical …

In-situ formable dextran/chitosan-based hydrogels functionalized with collagen and EGF for diabetic wounds healing

P Hu, Q Lei, S Duan, Y Fu, H Pan, C Chang… - Biomaterials …, 2022 - Elsevier
Delayed or non-healing skin wounds causing gangrene or even amputation, greatly threats
diabetic patients lives. Herein, a bioactive, in-situ formable hydrogel based wound dressing …

[HTML][HTML] Vitamin D mitigates diabetes-associated metabolic and cognitive dysfunction by modulating gut microbiota and colonic cannabinoid receptor 1

HM Hussein, MF Elyamany, LA Rashed… - European Journal of …, 2022 - Elsevier
Introduction Obesity is associated with elevated endocannabinoid tone, gut dysbiosis, and
inflammation predisposing to diabetes. The endocannabinoid system mediates the effects of …

Effect of Lactobacillus fermentum TKSN041 on improving streptozotocin-induced type 2 diabetes in rats

X Zhou, G Shang, Q Tan, Q He, X Tan, KY Park… - Food & Function, 2021 - pubs.rsc.org
With the increasing incidence of type 2 diabetes, it is imperative to identify how to effectively
prevent or treat this disease. Studies have shown that some lactic acid bacteria can improve …

[PDF][PDF] Effects of ginsenoside Rg1 on glucose metabolism and liver injury in streptozotocin-induced type 2 diabetic rats

W Tian, L Chen, L Zhang, B Wang, XB Li… - Genet Mol …, 2017 - m.jstshuichan.com
Type 2 diabetes mellitus (T2-DM) is a chronic metabolic disorder characterized by high
blood glucose levels. T2-DM patients suffer from many complications, such as diabetic fatty …