Epilepsy is a prevalent neurological disorder associated with significant morbidity and
mortality, but the only available drug therapies target its symptoms rather than the underlying …

Epilepsy is a common and serious neurologic disease with a strong genetic component.
Genetic studies have identified an increasing collection of disease-causing genes. The …

Diverse brain insults, including traumatic brain injury, stroke, infections, tumors,
neurodegenerative diseases, and prolonged acute symptomatic seizures, such as complex …

Experience-dependent brain plasticity typically declines after an early critical period during
which circuits are established. Loss of plasticity with closure of the critical period limits …

In many patients who suffer from epilepsies, recurrent epileptic seizures do not start at birth
but develop later in life. This holds particularly true for epilepsies with a focal seizure origin …

In cortical and hippocampal neurons, cation-chloride cotransporters (CCCs) control the
reversal potential (EGABA) of GABAA receptor-mediated current and voltage responses …

GABA is the main inhibitory neurotransmitter in the adult forebrain, where it activates
ionotropic type A and metabotropic type B receptors. Early studies have shown that GABAA …

Parvalbumin (Pv)-positive inhibitory interneurons effectively control network excitability, and
their optogenetic activation has been reported to block epileptic seizures. An intense activity …

It is just over a decade since the discovery of the first human epilepsy associated ion
channel gene mutation. Since then mutations in at least 25 different genes have been …

In the nematode Caenorhabditis elegans, cholinergic motor neurons stimulate muscle
contraction as well as activate GABAergic motor neurons that inhibit contraction of the …