Trends in peptide drug discovery
Since the introduction of insulin almost a century ago, more than 80 peptide drugs have
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis …
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis …
Photo-induced radical thiol–ene chemistry: a versatile toolbox for peptide-based drug design
While the global market for peptide/protein-based therapeutics is witnessing significant
growth, the development of peptide drugs remains challenging due to their low oral …
growth, the development of peptide drugs remains challenging due to their low oral …
Prospects for antibacterial discovery and development
TM Privalsky, AM Soohoo, J Wang… - Journal of the …, 2021 - ACS Publications
The rising prevalence of multidrug-resistant bacteria is an urgent health crisis that can only
be countered through renewed investment in the discovery and development of antibiotics …
be countered through renewed investment in the discovery and development of antibiotics …
[HTML][HTML] Esca** mechanisms of ESKAPE pathogens from antibiotics and their targeting by natural compounds
R Jadimurthy, SB Mayegowda, SC Nayak… - Biotechnology …, 2022 - Elsevier
The microorganisms that have developed resistance to available therapeutic agents are
threatening the globe and multidrug resistance among the bacterial pathogens is becoming …
threatening the globe and multidrug resistance among the bacterial pathogens is becoming …
Into the unknown: microbial communities in caves, their role, and potential use
K Kosznik-Kwaśnicka, P Golec, W Jaroszewicz… - Microorganisms, 2022 - mdpi.com
Caves have been an item of amateur and professional exploration for many years. Research
on the karst caves has revealed great diversity of bacteria, algae, and fungi living on stone …
on the karst caves has revealed great diversity of bacteria, algae, and fungi living on stone …
Discovery, optimization, and clinical application of natural antimicrobial peptides
Antimicrobial peptides (AMPs) are widespread in multicellular organisms. These structurally
diverse molecules are produced as the first line of defense against pathogens such as …
diverse molecules are produced as the first line of defense against pathogens such as …
Discovery, synthesis, and optimization of peptide-based antibiotics
CC Hanna, YO Hermant, PWR Harris… - Accounts of Chemical …, 2021 - ACS Publications
Conspectus The rise of multidrug resistant bacteria has significantly compromised our
supply of antibiotics and poses an alarming medical and economic threat to society. To …
supply of antibiotics and poses an alarming medical and economic threat to society. To …
[HTML][HTML] Phytochemicals and quaternary phosphonium ionic liquids: Connecting the dots to develop a new class of antimicrobial agents
Introduction The infections by multidrug-resistant bacteria are a growing threat to human
health, and the efficacy of the available antibiotics is gradually decreasing. As such, new …
health, and the efficacy of the available antibiotics is gradually decreasing. As such, new …
Natural products in antibiotic development: is the success story over?
Natural product (NP)-based antibiotics have been exploited for more than eighty years and
continue saving uncountable lives every year. However, antimicrobial R&D is inadequate to …
continue saving uncountable lives every year. However, antimicrobial R&D is inadequate to …
Improving phage therapy by evasion of phage resistance mechanisms
Antibiotic failure is one of the most worrisome threats to global health. Among the new
therapeutic efforts that are being explored, the use of bacteriophages (viruses that kill …
therapeutic efforts that are being explored, the use of bacteriophages (viruses that kill …