In red blood cell (RBC) diseases, the spleen contributes to anemia by clearing the damaged
RBCs, but its unique ability to mechanically challenge RBCs also poses the risk of inducing …

Cellular membranes span a wide range of spatio-temporal scales from sub-microsecond
dynamics of lipid molecules and intra-membrane proteins to multi-minute deformations of …

The spleen, the largest secondary lymphoid organ in humans, not only fulfils a broad range
of immune functions, but also plays an important role in red blood cell's (RBC) life cycle …

Computational Fluid Dynamics (CFD) is currently used to design and improve the hydraulic
properties of biomedical devices, wherein the large scale blood circulation needs to be …

Erythrophagocytosis occurring in the spleen is a critical process for removing senescent and
diseased red blood cells (RBCs) from the microcirculation. Although some progress has …

Erythrocytes in patients with type-2 diabetes mellitus (T2DM) are associated with reduced
cell deformability and elevated blood viscosity, which contribute to impaired blood flow and …

Emerging clinical evidence suggests that thrombosis in the microvasculature of patients with
Coronavirus disease 2019 (COVID-19) plays an essential role in dictating the disease …

Normal red blood cells (RBCs) have remarkable properties of deformability, which enable
them to squeeze through tiny splenic inter-endothelial slits (IESs) without any damage …

In red blood cell (RBC) disorders, such as sickle cell disease, hereditary spherocytosis, and
diabetes, alterations to the size and shape of RBCs due to either mutations of RBC proteins …

Microaneurysms (MAs) are one of the earliest clinically visible signs of diabetic retinopathy
(DR). MA leakage or rupture may precipitate local pathology in the surrounding neural retina …