Timing of lifespan influences on brain and cognition
Modifiable risk and protective factors for boosting brain and cognitive development and
preventing neurodegeneration and cognitive decline are embraced in neuroimaging …
preventing neurodegeneration and cognitive decline are embraced in neuroimaging …
Individual variations in 'brain age'relate to early-life factors more than to longitudinal brain change
Brain age is a widely used index for quantifying individuals' brain health as deviation from a
normative brain aging trajectory. Higher-than-expected brain age is thought partially to …
normative brain aging trajectory. Higher-than-expected brain age is thought partially to …
Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores
G Leonenko, E Baker, J Stevenson-Hoare… - Nature …, 2021 - nature.com
Abstract Polygenic Risk Scores (PRS) for AD offer unique possibilities for reliable
identification of individuals at high and low risk of AD. However, there is little agreement in …
identification of individuals at high and low risk of AD. However, there is little agreement in …
Impact of genetic predisposition to late-onset neurodegenerative diseases on early life outcomes and brain structure
Most patients with late-onset neurodegenerative diseases such as Alzheimer's and
Parkinson's have a complex aetiology resulting from numerous genetic risk variants of small …
Parkinson's have a complex aetiology resulting from numerous genetic risk variants of small …
[HTML][HTML] A recipe for accurate estimation of lifespan brain trajectories, distinguishing longitudinal and cohort effects
We address the problem of estimating how different parts of the brain develop and change
throughout the lifespan, and how these trajectories are affected by genetic and …
throughout the lifespan, and how these trajectories are affected by genetic and …
Polygenic risk score for Alzheimer's disease in Caribbean Hispanics
Objective Polygenic risk scores (PRSs) assess the individual genetic propensity to a
condition by combining sparse information scattered across genetic loci, often displaying …
condition by combining sparse information scattered across genetic loci, often displaying …
Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer's polygenic risk reveals autobiographical deficits and cingulate cortex correlates
Background Genome-wide association studies demonstrate that Alzheimer's disease (AD)
has a highly polygenic architecture, where thousands of independent genetic variants …
has a highly polygenic architecture, where thousands of independent genetic variants …
Serum cortisol is negatively related to hippocampal volume, brain structure, and memory performance in healthy aging and Alzheimer's disease
Objective Elevated cortisol levels have been frequently reported in Alzheimer's disease (AD)
and linked to brain atrophy, especially of the hippocampus. Besides, high cortisol levels …
and linked to brain atrophy, especially of the hippocampus. Besides, high cortisol levels …
Cognitive and hippocampal changes weeks and years after memory training
While immediate effects of memory-training are widely reported in young and older adults,
less is known regarding training-dependent hippocampal plasticity across multiple …
less is known regarding training-dependent hippocampal plasticity across multiple …
[HTML][HTML] Associations of circulating C-reactive proteins, APOE ε4, and brain markers for Alzheimer's disease in healthy samples across the lifespan
The apolipoprotein E gene ε4 allele (APOE ε4) and higher circulating level of C-reactive
protein (CRP) have been extensively investigated as risk factors for Alzheimer's disease …
protein (CRP) have been extensively investigated as risk factors for Alzheimer's disease …