Capillary forces generated by biomolecular condensates
Liquid–liquid phase separation and related phase transitions have emerged as generic
mechanisms in living cells for the formation of membraneless compartments or biomolecular …
mechanisms in living cells for the formation of membraneless compartments or biomolecular …
Theoretical and data-driven approaches for biomolecular condensates
Biomolecular condensation processes are increasingly recognized as a fundamental
mechanism that living cells use to organize biomolecules in time and space. These …
mechanism that living cells use to organize biomolecules in time and space. These …
Aging can transform single-component protein condensates into multiphase architectures
Phase-separated biomolecular condensates that contain multiple coexisting phases are
widespread in vitro and in cells. Multiphase condensates emerge readily within …
widespread in vitro and in cells. Multiphase condensates emerge readily within …
Fluorescent protein lifetimes report densities and phases of nuclear condensates during embryonic stem-cell differentiation
Fluorescent proteins (FP) are frequently used for studying proteins inside cells. In advanced
fluorescence microscopy, FPs can report on additional intracellular variables. One variable …
fluorescence microscopy, FPs can report on additional intracellular variables. One variable …
Construction of multiphasic membraneless organelles towards spontaneous spatial segregation and directional flow of biochemical reactions
Many intracellular membraneless organelles (MLOs) appear to adapt a hierarchical
multicompartment organization for efficient coordination of highly complex reaction …
multicompartment organization for efficient coordination of highly complex reaction …
Thermodynamic origins of two-component multiphase condensates of proteins
Intracellular condensates are highly multi-component systems in which complex phase
behaviour can ensue, including the formation of architectures comprising multiple …
behaviour can ensue, including the formation of architectures comprising multiple …
Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it
Biomolecular condensates, some of which are liquid-like during health, can age over time
becoming gel-like pathological systems. One potential source of loss of liquid-like properties …
becoming gel-like pathological systems. One potential source of loss of liquid-like properties …
Amphiphilic proteins coassemble into multiphasic condensates and act as biomolecular surfactants
Cells contain membraneless compartments that assemble due to liquid–liquid phase
separation, including biomolecular condensates with complex morphologies. For instance …
separation, including biomolecular condensates with complex morphologies. For instance …
Surface electrostatics govern the emulsion stability of biomolecular condensates
Liquid–liquid phase separation underlies the formation of biological condensates.
Physically, such systems are microemulsions that in general have a propensity to fuse and …
Physically, such systems are microemulsions that in general have a propensity to fuse and …
[HTML][HTML] Salt dependent phase behavior of intrinsically disordered proteins from a coarse-grained model with explicit water and ions
A Garaizar, JR Espinosa - The Journal of chemical physics, 2021 - pubs.aip.org
Multivalent proteins and nucleic acids can self-assemble into biomolecular condensates that
contribute to compartmentalize the cell interior. Computer simulations offer a unique view to …
contribute to compartmentalize the cell interior. Computer simulations offer a unique view to …